CYP26C1

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Cytochrome P450, family 26, subfamily C, polypeptide 1
Identifiers
Symbols CYP26C1 ; FFDD4
External IDs OMIM608428 MGI2679699 HomoloGene28089 GeneCards: CYP26C1 Gene
EC number 1.14.-.-
Orthologs
Species Human Mouse
Entrez 340665 546726
Ensembl ENSG00000187553 ENSMUSG00000062432
UniProt Q6V0L0 B2RXA7
RefSeq (mRNA) NM_183374 NM_001105201
RefSeq (protein) NP_899230 NP_001098671
Location (UCSC) Chr 10:
94.82 – 94.83 Mb
Chr 19:
37.69 – 37.69 Mb
PubMed search [1] [2]

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.[2]

CYP26C1 was found to show no expression in colorectal cancer cells or normal colonic epithelium.[3]

References[edit]

  1. ^ Taimi M, Helvig C, Wisniewski J, et al. (January 2004). "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid". J. Biol. Chem. 279 (1): 77–85. doi:10.1074/jbc.M308337200. PMID 14532297. 
  2. ^ "Entrez Gene: CYP26C1". 
  3. ^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. doi:10.1371/journal.pone.0090776. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.