CYP2A6

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Cytochrome P450, family 2, subfamily A, polypeptide 6
Protein CYP2A6 PDB 1z10.png
PDB rendering based on 1z10.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CYP2A6 ; CPA6; CYP2A; CYP2A3; CYPIIA6; P450C2A; P450PB
External IDs OMIM122720 HomoloGene85917 ChEMBL: 5282 GeneCards: CYP2A6 Gene
EC number 1.14.14.1
Orthologs
Species Human Mouse
Entrez 1548 13086
Ensembl ENSG00000198077 ENSMUSG00000074254
UniProt P11509 P15392
RefSeq (mRNA) NM_000762 NM_009997
RefSeq (protein) NP_000753 NP_034127
Location (UCSC) Chr 19:
41.35 – 41.36 Mb
Chr 7:
26.31 – 26.32 Mb
PubMed search [1] [2]

Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

The CYP2A6 gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.[1]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 

Distribution[edit]

CYP2A6 localizes to the endoplasmic reticulum and is found predominantly in the liver.

Variability[edit]

Significant interindividual variability in CYP2A6 apoprotein and mRNA levels has been observed.

Induction[edit]

CYP2A6 is known to be inducible by phenobarbital and rifampicin, and it is suspected that other antiepileptic drugs may also have this effect.

CYP2A6 Ligands[edit]

Selected inducers, inhibitors and substrates of CYP2A6[citation needed]
Substrates Inhibitors Inducers

References[edit]

Further reading[edit]