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Cytochrome P450, family 2, subfamily U, polypeptide 1
Symbols CYP2U1 ; P450TEC; SPG49; SPG56
External IDs OMIM610670 MGI1918769 HomoloGene77704 GeneCards: CYP2U1 Gene
EC number
Species Human Mouse
Entrez 113612 71519
Ensembl ENSG00000155016 ENSMUSG00000027983
UniProt Q7Z449 Q9CX98
RefSeq (mRNA) NM_183075 NM_027816
RefSeq (protein) NP_898898 NP_082092
Location (UCSC) Chr 4:
108.85 – 108.87 Mb
Chr 3:
131.29 – 131.3 Mb
PubMed search [1] [2]

CYP2U1 (cytochrome P450, family 2, subfamily U, polypeptide 1) is a protein that in humans is encoded by the CYP2U1 gene[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[2] CYP2U1 metabolized arachidonic acid, docosahexaenoic acid (DHA), and other long chain fatty acids which suggests that CYP2U1 may play a role in brain and immune functions.[1] CYP2U1 also metabolizes propanone, acetone, and 2-oxypropane.


  1. ^ a b Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B (February 2004). "CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids". J. Biol. Chem. 279 (8): 6305–14. doi:10.1074/jbc.M311830200. PMID 14660610. 
  2. ^ "Entrez Gene: CYP2U1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.