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Cytochrome P450, family 46, subfamily A, polypeptide 1
Protein CYP46A1 PDB 2Q9F.png
Rendering based on PDB 2Q9F.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CYP46A1 ; CP46; CYP46
External IDs OMIM604087 MGI1341877 HomoloGene134501 IUPHAR: 1373 GeneCards: CYP46A1 Gene
EC number
RNA expression pattern
PBB GE CYP46A1 220331 at tn.png
More reference expression data
Species Human Mouse
Entrez 10858 13116
Ensembl ENSG00000036530 ENSMUSG00000021259
UniProt Q9Y6A2 Q9WVK8
RefSeq (mRNA) NM_006668 NM_010010
RefSeq (protein) NP_006659 NP_034140
Location (UCSC) Chr 14:
100.15 – 100.19 Mb
Chr 12:
108.33 – 108.36 Mb
PubMed search [1] [2]

Cholesterol 24-hydroxylase is an enzyme that in humans is encoded by the CYP46A1 gene.[1][2]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood–brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.[2]


Further reading[edit]