CYP4B1

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Cytochrome P450, family 4, subfamily B, polypeptide 1
Identifiers
Symbols CYP4B1 ; CYPIVB1; P-450HP
External IDs OMIM124075 MGI103225 HomoloGene128045 GeneCards: CYP4B1 Gene
EC number 1.14.14.1
RNA expression pattern
PBB GE CYP4B1 210096 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1580 13120
Ensembl ENSG00000142973 ENSMUSG00000028713
UniProt P13584 Q64462
RefSeq (mRNA) NM_000779 NM_007823
RefSeq (protein) NP_000770 NP_031849
Location (UCSC) Chr 1:
47.22 – 47.29 Mb
Chr 4:
115.62 – 115.65 Mb
PubMed search [1] [2]

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.[1]

Mouse Mutant Alleles for Cyp4b1
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI Cyp4b1
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. CYP4B1tm1a(KOMP)Wtsi
Example structure of targeted conditional mutant allele for this gene
Molecular structure of Cyp4b1 region with inserted mutation sequence
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Cyp4b1:

see Knockout mouse

References[edit]

Further reading[edit]

  • Windmill KF, McKinnon RA, Zhu X, et al. (1997). "The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.". Mutat. Res. 376 (1-2): 153–60. doi:10.1016/S0027-5107(97)00038-9. PMID 9202751. 
  • Hakkola J, Pelkonen O, Pasanen M, Raunio H (1998). "Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity.". Crit. Rev. Toxicol. 28 (1): 35–72. doi:10.1080/10408449891344173. PMID 9493761. 
  • Yokotani N, Sogawa K, Matsubara S, et al. (1990). "cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression.". Eur. J. Biochem. 187 (1): 23–9. doi:10.1111/j.1432-1033.1990.tb15273.x. PMID 2298205. 
  • Nhamburo PT, Gonzalez FJ, McBride OW, et al. (1990). "Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping.". Biochemistry 28 (20): 8060–6. doi:10.1021/bi00446a014. PMID 2574990. 
  • McKinnon RA, Burgess WM, Gonzalez FJ, et al. (1995). "Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues.". Pharmacogenetics 4 (5): 260–70. doi:10.1097/00008571-199410000-00004. PMID 7894498. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ (1994). "Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors.". Cancer Res. 54 (4): 1085–91. PMID 8313365. 
  • Hakkola J, Raunio H, Purkunen R, et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.". Biochem. Pharmacol. 52 (2): 379–83. doi:10.1016/0006-2952(96)00216-X. PMID 8694864. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Hukkanen J, Hakkola J, Anttila S, et al. (1997). "Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.". Mol. Carcinog. 20 (2): 224–30. doi:10.1002/(SICI)1098-2744(199710)20:2<224::AID-MC9>3.0.CO;2-M. PMID 9364212. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Hukkanen J, Mäntylä M, Kangas L, et al. (1998). "Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium.". Pharmacol. Toxicol. 82 (2): 93–7. doi:10.1111/j.1600-0773.1998.tb01404.x. PMID 9498238. 
  • Thum T, Borlak J (2000). "Gene expression in distinct regions of the heart.". Lancet 355 (9208): 979–83. doi:10.1016/S0140-6736(00)99016-0. PMID 10768437. 
  • Imaoka S, Yoneda Y, Sugimoto T, et al. (2000). "CYP4B1 is a possible risk factor for bladder cancer in humans.". Biochem. Biophys. Res. Commun. 277 (3): 776–80. doi:10.1006/bbrc.2000.3740. PMID 11062028. 
  • Henne KR, Kunze KL, Zheng YM, et al. (2001). "Covalent linkage of prosthetic heme to CYP4 family P450 enzymes.". Biochemistry 40 (43): 12925–31. doi:10.1021/bi011171z. PMID 11669629. 
  • Finnström N, Bjelfman C, Söderström TG, et al. (2002). "Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR.". Eur. J. Clin. Invest. 31 (10): 880–6. doi:10.1046/j.1365-2362.2001.00893.x. PMID 11737226. 
  • Iscan M, Klaavuniemi T, Coban T, et al. (2002). "The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue.". Breast Cancer Res. Treat. 70 (1): 47–54. doi:10.1023/A:1012526406741. PMID 11767004. 
  • Lo-Guidice JM, Allorge D, Cauffiez C, et al. (2003). "Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant.". Pharmacogenetics 12 (5): 367–74. doi:10.1097/00008571-200207000-00004. PMID 12142726.