CYP4F2

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Cytochrome P450, family 4, subfamily F, polypeptide 2
Identifiers
Symbols CYP4F2 ; CPF2
External IDs OMIM604426 MGI2158641 HomoloGene128623 ChEMBL: 3379 GeneCards: CYP4F2 Gene
EC number 1.14.13.30
RNA expression pattern
PBB GE CYP4F2 210452 x at tn.png
PBB GE CYP4F2 206514 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8529 72054
Ensembl ENSG00000186115 ENSMUSG00000003484
UniProt P78329 Q99N16
RefSeq (mRNA) NM_001082 NM_024444
RefSeq (protein) NP_001073 NP_077764
Location (UCSC) Chr 19:
15.99 – 16.01 Mb
Chr 8:
71.99 – 72.01 Mb
PubMed search [1] [2]

Leukotriene-B(4) omega-hydroxylase 1 is an enzyme that in humans is encoded by the CYP4F2 gene.[1][2][3]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.[3]

References[edit]

  1. ^ Chen L, Hardwick JP (Feb 1993). "Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors". Arch Biochem Biophys 300 (1): 18–23. doi:10.1006/abbi.1993.1003. PMID 8424651. 
  2. ^ Kikuta Y, Kusunose E, Kondo T, Yamamoto S, Kinoshita H, Kusunose M (Aug 1994). "Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver". FEBS Lett 348 (1): 70–4. doi:10.1016/0014-5793(94)00587-7. PMID 8026587. 
  3. ^ a b "Entrez Gene: CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2". 

Further reading[edit]