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Cytochrome P450, family 4, subfamily F, polypeptide 22
Symbols CYP4F22 ; ARCI5; INLNE; LI3
External IDs OMIM611495 MGI2445210 HomoloGene69814 GeneCards: CYP4F22 Gene
EC number 1.14.14.-
Species Human Mouse
Entrez 126410 320997
Ensembl ENSG00000171954 ENSMUSG00000061126
UniProt Q6NT55 Q8BGU0
RefSeq (mRNA) NM_173483 NM_177307
RefSeq (protein) NP_775754 NP_796281
Location (UCSC) Chr 19:
15.62 – 15.66 Mb
Chr 17:
32.47 – 32.49 Mb
PubMed search [1] [2]

CYP4F22 (cytochrome P450, family 4, subfamily F, polypeptide 22) is a protein that in humans is encoded by the CYP4F22 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3.[2]


  1. ^ Lefèvre C, Bouadjar B, Ferrand V, Tadini G, Mégarbané A, Lathrop M, Prud'homme JF, Fischer J (March 2006). "Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3". Hum. Mol. Genet. 15 (5): 767–76. doi:10.1093/hmg/ddi491. PMID 16436457. 
  2. ^ "Entrez Gene: CYP4F22". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.