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Cytochrome P450, family 4, subfamily Z, polypeptide 1
Symbols CYP4Z1 ; CYP4A20
External IDs HomoloGene79596 IUPHAR: 1352 GeneCards: CYP4Z1 Gene
EC number
Species Human Mouse
Entrez 199974 n/a
Ensembl ENSG00000186160 n/a
UniProt Q86W10 n/a
RefSeq (mRNA) NM_178134 n/a
RefSeq (protein) NP_835235 n/a
Location (UCSC) Chr 1:
47.53 – 47.58 Mb
PubMed search [1] n/a

CYP4Z1 (cytochrome P450, family 4, subfamily Z, polypeptide 1) is a protein that in humans is encoded by the CYP4Z1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.[2]

CYP4Z1 is overexpressed in breast cancer cells.[1] It has also been demonstrated that the expression of the CYP4Z1 gene is upregulated by activated glucocorticoid and progesterone receptors.[3]


  1. ^ a b Rieger MA, Ebner R, Bell DR, Kiessling A, Rohayem J, Schmitz M, Temme A, Rieber EP, Weigle B (April 2004). "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma". Cancer Res. 64 (7): 2357–64. doi:10.1158/0008-5472.CAN-03-0849. PMID 15059886. 
  2. ^ "Entrez Gene: CYP4Z1". 
  3. ^ Savas U, Hsu MH, Griffin KJ, Bell DR, Johnson EF (April 2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. doi:10.1016/ PMID 15797250. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.