|Jmol-3D images||Image 1|
|Molar mass||316.43 g mol−1|
|Melting point||158 to 162 °C; 316 to 324 °F; 431 to 435 K|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
A typical bean of Coffea arabica contains about 0.6% cafestol by weight. Cafestol is present in highest quantity in unfiltered coffee drinks such as French press coffee or Turkish coffee/Greek coffee. In filtered coffee drinks such as drip brewed coffee, it is present in only negligible amounts.
Potential biological activity
Cafestol has also shown anticarcinogenic properties in rats. Cafestol may act as an agonist ligand for the nuclear receptor farnesoid X receptor and pregnane X receptor, blocking cholesterol homeostasis. Cafestol also has neuroprotective effects in a Drosophila fruit fly model of Parkinson's disease. Cafestol and kahweol from coffee extracts have been claimed as beneficial in the treatment of mesothelioma.
- National Toxicology Program (NTP): Cafestol (CASRN 469-83-0) and Kahweol (CASRN 6894-43-5) - Review of Toxicological Literature. (PDF) October 1999
- Ricketts ML, Boekschoten MV, Kreeft AJ, Hooiveld GJ, Moen CJ, Müller M, Frants RR, Kasanmoentalib S, Post SM, Princen HM, Porter JG, Katan MB, Hofker MH, Moore DD (July 2007). "The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors". Mol. Endocrinol. 21 (7): 1603–16. doi:10.1210/me.2007-0133. PMID 17456796.
- Trinh K, Andrews L, Krause J, Hanak T, Lee D, Gelb M, Pallanck L (April 2010). "Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism". J. Neurosci. 30 (16): 5525–32. doi:10.1523/JNEUROSCI.4777-09.2010. PMID 20410106. Lay summary – New Scientist.
- Jeong Hyeon Sim, “Cafestol and kahweol from coffee extracts for treating malignant pleural mesothelioma”, KR Patent CN 2,013,119,032 (2013)