Caffeic acid phenethyl ester

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Caffeic acid phenethyl ester
Phenethyl caffeate.svg
Identifiers
Abbreviations CAPE
CAS number 104594-70-9
PubChem 5281787
ChemSpider 4445100
ChEBI CHEBI:8062
Jmol-3D images Image 1
Properties
Molecular formula C17H16O4
Molar mass 284.31 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Caffeic acid phenethyl ester (CAPE) is a natural phenolic chemical compound. It is the ester of caffeic acid and phenethyl alcohol.

Natural occurrences[edit]

CAPE is found in a variety of plants. It is also a component of propolis from honeybee hives.[1]

Health effects[edit]

A variety of in vitro pharmacology for CAPE has been reported. A study using CAPE showed a positive effect on reducing carcinogenic incidence. It is known to have antimitogenic, anticarcinogenic, anti-inflammatory, and immunomodulatory properties in vitro.[2] Another study also showed that CAPE suppresses acute immune and inflammatory responses and holds promise for therapeutic uses to reduce inflammation.[3] This anti-cancer effect was also seen when mice skin was treated with bee propolis and exposed to TPA, a chemical that induced skin papillomas. CAPE significantly reduced the number of papillomas.[4][5]

References[edit]

  1. ^ Demestre M, Messerli SM, Celli N et al. (August 2008). "CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice". Phytother Res 23 (2): 226–30. doi:10.1002/ptr.2594. PMID 18726924. 
  2. ^ Natarajan K, Singh S, Burke TR, Grunberger D, Aggarwal BB (August 1996). "Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B". Proc. Natl. Acad. Sci. U.S.A. 93 (17): 9090–5. doi:10.1073/pnas.93.17.9090. PMC 38600. PMID 8799159. 
  3. ^ Orban Z, Mitsiades N, Burke TR, Tsokos M, Chrousos GP (2000). "Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation". Neuroimmunomodulation 7 (2): 99–105. doi:10.1159/000026427. PMID 10686520. 
  4. ^ Huang MT, Ma W, Yen P et al. (April 1996). "Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells". Carcinogenesis 17 (4): 761–5. doi:10.1093/carcin/17.4.761. PMID 8625488. 
  5. ^ Huang MT, Smart RC, Wong CQ, Conney AH (November 1988). "Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate". Cancer Res. 48 (21): 5941–6. PMID 3139287.