Cairo is an unincorporated community in Malheur County, Oregon, United States. Its elevation is 2192 feet (668 m). It is about four miles (6 km) southwest of Ontario and a half mile north of Cairo Junction, an intersection where U.S. Route 20/U.S. Route 26, running concurrently with Oregon Route 201, turn south towards Nyssa. OR 201 also continues north from Cairo Junction through Cairo and towards Ontario. Cairo was a station on the Oregon Short Line Railroad (OSL) to Vale. The OSL line is now part of the Union Pacific mainline. Cairo Elementary School in Cairo Junction is part of the Ontario School District; the school was built in 1957.
Coordinates: 43°59′46″N 117°00′33″W / 43.995997°N 117.009051°W