Calcium-activated chloride channel

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Calcium-activated chloride channel
Identifiers
Symbol CLCA_N
Pfam PF08434
InterPro IPR013642

The family of calcium-activated chloride channels (CaCCs),[1] which includes "chloride channel accessory" (CLCA),[2] bestrophin (BEST),[3][4] and anoctamin (ANO)[3][4][5] channels, have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal.[5] Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors.[6]

Human calcium-activated chloride channels[edit]

Medical use[edit]

ANO1 is inhibited by the anti-diarrhoea drug crofelemer and activated by the cholinergic drug, carbachol.

References[edit]

  1. ^ http://www.ncbi.nlm.nih.gov/pubmed/15709976
  2. ^ "CLCA1 chloride channel accessory 1 [Homo sapiens (human)] - Gene - NCBI". 
  3. ^ a b Kunzelmann K, Kongsuphol P, Chootip K, Toledo C, Martins JR, Almaca J, Tian Y, Witzgall R, Ousingsawat J, Schreiber R (January 2011). "Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells". Biol. Chem. 392 (1-2): 125–34. doi:10.1515/BC.2011.010. PMID 21194364. 
  4. ^ a b Kunzelmann K, Kongsuphol P, Aldehni F, Tian Y, Ousingsawat J, Warth R, Schreiber R (October 2009). "Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions". Cell Calcium 46 (4): 233–41. doi:10.1016/j.ceca.2009.09.003. PMID 19783045. 
  5. ^ a b Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM (February 2012). "Anoctamins and gastrointestinal smooth muscle excitability". Exp. Physiol. 97 (2): 200–206. doi:10.1113/expphysiol.2011.058248. PMC 3272164. PMID 22002868. 
  6. ^ Evans SR, Thoreson WB, Beck CL (2004). "Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine". J. Biol. Chem. 279 (40): 41792–41800. doi:10.1074/jbc.M408354200. PMID 15284223. 

External links[edit]

This article incorporates text from the public domain Pfam and InterPro IPR013642