family of calcium-activated chloride channels (CaCCs), which includes " [1 ] chloride channel accessory" (CLCA), [2 ] bestrophin (BEST), [3 ] and [4 ] anoctamin (ANO) [3 ] [4 ] channels, have been identified in many [5 ] epithelial and endothelial cell types as well as in smooth muscle cells. ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as [5 ] tumour suppressors. [6 ]
Human calcium-activated chloride channels [ edit ]
Medical use [ edit ]
ANO1 is inhibited by the anti-diarrhoea drug crofelemer and activated by the cholinergic drug, carbachol.
References [ edit ]
^ "CLCA1 chloride channel accessory 1 [Homo sapiens (human)] - Gene - NCBI".
^ a b Kunzelmann K, Kongsuphol P, Chootip K, Toledo C, Martins JR, Almaca J, Tian Y, Witzgall R, Ousingsawat J, Schreiber R (January 2011). "Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells". Biol. Chem. 392 (1-2): 125–34. doi: 10.1515/BC.2011.010. PMID 21194364.
^ a b Kunzelmann K, Kongsuphol P, Aldehni F, Tian Y, Ousingsawat J, Warth R, Schreiber R (October 2009). "Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions". Cell Calcium 46 (4): 233–41. doi: 10.1016/j.ceca.2009.09.003. PMID 19783045.
^ a b Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM (February 2012). "Anoctamins and gastrointestinal smooth muscle excitability". Exp. Physiol. 97 (2): 200–206. doi: 10.1113/expphysiol.2011.058248. PMC 3272164. PMID 22002868.
^ Evans SR, Thoreson WB, Beck CL (2004). "Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine". J. Biol. Chem. 279 (40): 41792–41800. doi: 10.1074/jbc.M408354200. PMID 15284223.
External links [ edit ]
This article incorporates text from the public domain Pfam and InterPro IPR013642