Calcium-activated chloride channel

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Calcium-activated chloride channel
Identifiers
Symbol CLCA_N
Pfam PF08434
InterPro IPR013642

The family of calcium-activated chloride channels (CaCCs),[1] which includes chloride channel accessory (CLCA),[2] bestrophin (BEST),[3][4] and anoctamin (ANO) channels (also known as the TMEM16 family),[3][4][5][6] have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal.[5] In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors.[7]

Human calcium-activated chloride channels[edit]

Medical use[edit]

ANO1 is inhibited by the anti-diarrhoea drug crofelemer and activated by the cholinergic drug, carbachol.

References[edit]

  1. ^ Hartzell, Criss; Putzler, Ilva; Arreola, Jorge (March 2005). "Calcium-activated Chloride Channels". Annual Review of Physiology 76: 719–58. doi:10.1146/annurev.physiol.67.032003.154341. PMID 15709976. Closed access
  2. ^ "CLCA1 chloride channel accessory 1 [Homo sapiens (human)]". Gene. National Center for Biotechnology Information. 13 January 2015. 
  3. ^ a b Kunzelmann, K; Kongsuphol, P.; Chootip, K. et al. (January 2011). "Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells". Biological Chemistry 392 (1–2): 125–34. doi:10.1515/BC.2011.010. PMID 21194364. 
  4. ^ a b Kunzelmann, K; Kongsuphol, P; Aldehni, F et al. (October 2009). "Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions". Cell Calcium 46 (4): 233–41. doi:10.1016/j.ceca.2009.09.003. PMID 19783045. 
  5. ^ a b Sanders, KM; Zhu, MH; Britton, F et al. (February 2012). "Anoctamins and gastrointestinal smooth muscle excitability". Experimental Physiology 97 (2): 200–6. doi:10.1113/expphysiol.2011.058248. PMC 3272164. PMID 22002868. open access publication - free to read
  6. ^ a b c d e Brunner, Janine D.; Lim, Novandy K.; Schenck, Stephen et al. (11 December 2014). "X-ray structure of a calcium-activated TMEM16 lipid scramblase". Nature 516 (7530): 207–12. doi:10.1038/nature13984. 
  7. ^ Evans, SR; Thoreson, WB; Beck, CL (2004). "Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine". Journal of Biological Chemistry 279 (40): 41792–800. doi:10.1074/jbc.M408354200. PMC 1383427. PMID 15284223. 

External links[edit]

This article incorporates text from the public domain Pfam and InterPro IPR013642