Calcium carbimide

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Calcium carbimide
Citrated calcium carbimide.png
Systematic (IUPAC) name
calcium 2-hydroxypropane-1,2,3-tricarboxylate; methylcyanamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Identifiers
CAS number 8013-88-5 YesY
ATC code N07BB02
PubChem CID 6335910
ChemSpider 21106422 YesY
UNII ZLR270912W N
ChEMBL CHEMBL2106095 N
Chemical data
Formula C6H8O7.CH2N2.Ca
Mol. mass 288.268 g/mol
 N (what is this?)  (verify)

Calcium carbimide, sold as the citrate salt under the trade name Temposil, is an alcohol sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.

A recent 9-year study found that incorporation of supervised carbimide and the similar drug, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50%.[1]

Temposil was developed by Drs. Ken Ferguson and Gordon Bell, who self-tested the drug on themselves.[2] [3] [4] It was patented in 1955 by the Alcoholism Research Foundation of Ontario.[5]

See also[edit]

References[edit]

  1. ^ Krampe H, Stawicki S, Wagner T, et al. (January 2006). "Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome". Alcoholism, clinical and experimental research 30 (1): 86–95. doi:10.1111/j.1530-0277.2006.00013.x. ISSN 0145-6008. PMID 16433735. 
  2. ^ "Ogspi "PLO" 2005 Obituary". Ontario Genealogical Society. 
  3. ^ "Deaths - Canadian Medical Association Journal". Canadian Medical Association Journal. 
  4. ^ "Pioneer in Addiction Treatment Dr. Robert Gordon Bell Leaves Behind a Legacy of Hope and Healing". Ontario Federation of Community Mental Health and Addiction Programs. 
  5. ^ "Booze: A Distilled History". Between The Lines. 2003.