Caldesmon

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Caldesmon 1
Identifiers
Symbols CALD1 ; CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
External IDs OMIM114213 HomoloGene69531 GeneCards: CALD1 Gene
RNA expression pattern
PBB GE CALD1 201616 s at tn.png
PBB GE CALD1 201615 x at tn.png
PBB GE CALD1 201617 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 800 n/a
Ensembl ENSG00000122786 n/a
UniProt Q05682 n/a
RefSeq (mRNA) NM_004342 n/a
RefSeq (protein) NP_004333 n/a
Location (UCSC) Chr 7:
134.43 – 134.66 Mb
n/a
PubMed search [1] n/a

Caldesmon is a protein that in humans is encoded by the CALD1 gene.[1][2]

Caldesmon is a calmodulin binding protein. Like calponin or troponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.[2]

Immunochemistry[edit]

In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

References[edit]

  1. ^ Novy RE, Lin JL, Lin JJ (Oct 1991). "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells". J Biol Chem 266 (25): 16917–24. PMID 1885618. 
  2. ^ a b "Entrez Gene: CALD1 caldesmon 1". 

Further reading[edit]


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