Calea ternifolia (syn. Calea zacatechichi) is a species of flowering plant in the aster family, Asteraceae. It is native to Mexico and Central America. Its English language common names include Thepelakano (leaves of god), bitter-grass, Mexican calea, and dream herb.
In Mexico the plant is used as an herbal remedy for dysentery and fever. The Zoque Popoluca people call the plant tam huñi ("bitter gum") and use it to treat diarrhea and asthma, and the Mixe people know it as poop taam ujts ("white bitter herb") and use it for stomachache and fever.
The Chontal people of Oaxaca reportedly use the plant, known locally as thle-pela-kano, during divination. Isolated reports describe rituals that involve smoking a plant believed to be this species, drinking it as a tea, and placing it under a pillow to induce divinatory dreams. Zacatechichi, the former species name, is a Nahuatl word meaning "bitter grass". Users take the plant to help them remember their dreams; side effects include hallucinations, nausea, and vomiting.
While quite bitter if brewed in hot water, the bitterness can be considerably masked by brewing with Osmanthus flowers, which have a compatible scent profile.
Chemical compounds isolated from this species include flavones such as acacetin and sesquiterpene lactones such as germacranolides. The sesquiterpenes known as caleicines and caleochromenes may be active in its effects on sleep.
While it is not a controlled substance under federal law in the United States, some states have considered it individually. Louisiana State Act 159 specifies that it is illegal to possess 40 or more plants if they are intended for consumption, but not if they are intended for ornamental or landscaping use. Tennessee proposed a bill that would have made illegal this and many other plants classified as hallucinogenic, but when the bill was passed only Salvia divinorum was banned.
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