The Calliope River is located in Central Queensland, Australia. The river rises in the Calliope Range inland from the industrial port city of Gladstone, flows past the town of Calliope, before emptying into the Pacific Ocean just north of Gladstone. River length is approximately 100 kilometres, with a catchment area of approximately 2230 square kilometres.
Oakey, Paddock and Larcom Creeks are the main tributaries of the river. The major industry in the river area is the raising of beef cattle.
Like others along the tropical coast of Australia, the river contains a rare germ which destroys flesh. The waters of the river may also contain box jellyfish for many kilometres upstream. This venomous, marine animal poses a threat to swimmers.