|UN number||3077 keshav|
|Jmol-3D images||Image 1|
|Molar mass||472.09 g/mol|
|Melting point||525 °C (triple point)|
|Boiling point||383 °C (sublimes)|
|Solubility in water||0.2 mg/100 mL|
|Solubility||insoluble in ethanol, ether|
|Refractive index (nD)||1.973|
|EU classification||Harmful (Xn)
Dangerous for the environment (N)
|R-phrases||R22, R36/37/38, R50/53|
|S-phrases||(S2), S13, S24/25, S46, S60, S61|
|Std enthalpy of
|Other anions||Mercury(I) fluoride
|Other cations||Mercury(II) chloride|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
Mercury(I) chloride is the chemical compound with the formula Hg2Cl2. Also known as calomel (a mineral form, rarely found in nature) or mercurous chloride, this dense white or yellowish-white, odorless solid is the principal example of a mercury(I) compound. It is a component of reference electrodes in electrochemistry.
The name calomel is thought to come from the Greek κάλλος beautiful, and μέλας black. This name (somewhat surprising for a white compound) is probably due to its characteristic disproportionation reaction with ammonia, which gives a spectacular black coloration due to the finely dispersed metallic mercury formed. It is also referred to as the mineral horn quicksilver or horn mercury. Calomel was taken internally and used as a laxative and disinfectant, as well as in the treatment of syphilis, until the early 20th century. Until fairly recently it was also used as a horticultural fungicide, most notably as a root dip to help prevent the occurrence of clubroot amongst crops of the Brassicaceae family.
Mercury became a popular remedy for a variety of physical and mental ailments during the age of "heroic medicine." It was used by doctors in America throughout the 18th century, and during the revolution, to make patients regurgitate and release their body from "impurities". Benjamin Rush was one particular well-known advocate of mercury in medicine and used calomel to treat sufferers of yellow fever during its outbreak in Philadelphia in 1793. Calomel was given to patients as a purgative or cathartic until they began to salivate and was often administered to patients in such great quantities that their hair and teeth fell out. Shortly after yellow fever struck Philadelphia, the disease broke out in Jamaica. A war of words erupted in the press concerning the best treatment for yellow fever; bleeding or calomel. Anecdotal evidence indicates calomel was more effective than bleeding.
Mercury is unique among the group 12 metals for its ability to form the M–M bond so readily. Hg2Cl2 is a linear molecule. The mineral calomel crystallizes in the tetragonal system, with space group I4/m 2/m 2/m. The unit cell of the crystal structure is shown below:
The Hg–Hg bond length of 253 pm (Hg–Hg in the metal is 300 pm) and the Hg–Cl bond length in the linear Hg2Cl2 unit is 243 pm. The overall coordination of each Hg atom is octahedral as, in addition to the two nearest neighbours, there are four other Cl atoms at 321 pm. Longer mercury polycations exist.
Preparation and reactions
Mercurous chloride forms by the reaction of elemental mercury and mercuric chloride:
- Hg + HgCl2 → Hg2Cl2
- 2HCl + Hg2(NO3)2 → Hg2Cl2 + 2HNO3
- Hg2Cl2 + 2NH3 → Hg + Hg(NH2)Cl + NH4Cl
Mercurous chloride is employed extensively in electrochemistry, taking advantage of the ease of its oxidation and reduction reactions. The calomel electrode is a reference electrode, especially in older publications. Over the past 50 years, it has been superseded by the silver/silver chloride (Ag/AgCl) electrode. Although the mercury electrodes have been widely abandoned due to the dangerous nature of mercury, many chemists believe they are still more accurate and are not dangerous as long as they are handled properly. The differences in experimental potentials vary little from literature values. Other electrodes can vary by 70 to 100 millivolts.
Mercurous chloride decomposes into mercury(II) chloride and elemental mercury upon exposure to UV light.
- Hg2Cl2 → HgCl2 + Hg
The formation of Hg can be used to calculate the number of photons in the light beam, by the technique of actinometry. By utilizing a light reaction in the presence of mercury(II) chloride and ammonium oxalate, mercury(I) chloride, ammonium chloride and carbon dioxide is produced.
- 2HgCl2 + (NH4)2C2O4 + Light → Hg2Cl2(s) + 2[NH4+][Cl−] + 2CO2
This particular reaction was discovered by J.M. Eder (hence the name Eder reaction) in 1880 and reinvestigated by W. E. Rosevaere in 1929
Related mercury(I) compounds
Mercurous chloride is toxic, although due to its low solubility in water it is generally less dangerous than its mercuric chloride counterpart. It was used in medicine as a diuretic and purgative (laxative) in the United States from the early 1830s through the 1860s. Calomel was also a common ingredient in teething powders in Britain up until 1954, causing widespread mercury poisoning in the form of pink disease, which at the time had a mortality rate of 1 in 10. These medicinal uses were later discontinued when the compound's toxicity was discovered.
It has also found uses in cosmetics as soaps and skin lightening creams, but these preparations are now illegal to manufacture or import in many countries including the U.S., Canada, Japan and the European Union. A study of workers involved in the production of these preparations showed that the sodium salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS) was effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels.
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- D. Gonzalez-Ramirez, M. Zuniga-Charles, A. Narro-Juarez, Y. Molina-Recio, K. M. Hurlbut, R. C. Dart and H. V. Aposhian (1 October 1998). "DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride" (free full text). Journal of Pharmacology and Experimental Therapy 287 (1): 8–12. PMID 9765315.
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