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Symbols CAST ; BS-17
External IDs OMIM114090 MGI1098236 HomoloGene7658 GeneCards: CAST Gene
RNA expression pattern
PBB GE CAST 212586 at tn.png
PBB GE CAST 207467 x at tn.png
PBB GE CAST 208908 s at tn.png
More reference expression data
Species Human Mouse
Entrez 831 12380
Ensembl ENSG00000153113 ENSMUSG00000021585
UniProt P20810 P51125
RefSeq (mRNA) NM_001042440 NM_001301153
RefSeq (protein) NP_001035905 NP_001288082
Location (UCSC) Chr 5:
95.86 – 96.12 Mb
Chr 13:
74.69 – 74.81 Mb
PubMed search [1] [2]

Calpastatin is a protein that in humans is encoded by the CAST gene.[1][2][3][4]

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length natures of only some have been determined.[4]


  1. ^ Ma H, Yang HQ, Takano E, Lee WJ, Hatanaka M, Maki M (Sep 1993). "Requirement of different subdomains of calpastatin for calpain inhibition and for binding to calmodulin-like domains". J Biochem 113 (5): 591–9. PMID 8340353. 
  2. ^ Averna M, De Tullio R, Capini P, Salamino F, Pontremoli S, Melloni E (Dec 2003). "Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca(2+)-dependent proteolysis". Cell Mol Life Sci 60 (12): 2669–78. doi:10.1007/s00018-003-3288-0. PMID 14685690. 
  3. ^ Raynaud P, Jayat-Vignoles C, Laforet MP, Leveziel H, Amarger V (Apr 2005). "Four promoters direct expression of the calpastatin gene". Arch Biochem Biophys 437 (1): 69–77. doi:10.1016/ PMID 15820218. 
  4. ^ a b "Entrez Gene: CAST calpastatin". 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: LI27.001

Further reading[edit]