Calponin family repeat

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Symbol Calponin
Pfam PF00402
InterPro IPR000557

In molecular biology, the calponin family repeat is a 26 amino acid protein domain. Calponin-1 (CNN1) contains three copies of this domain. This domain is also found in vertebrate smooth muscle protein (SM22 or transgelin), and a number of other proteins whose physiological role is not yet established, including Drosophila synchronous flight muscle protein SM20, Caenorhabditis elegans unc-87 protein,[1] rat neuronal protein NP25,[2] and an Onchocerca volvulus antigen.[3]


  1. ^ Goetinck S, Waterston RH (October 1994). "The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein". J. Cell Biol. 127 (1): 79–93. doi:10.1083/jcb.127.1.79. PMC 2120179. PMID 7929573. 
  2. ^ Ren WZ, Ng GY, Wang RX, Wu PH, O'Dowd BF, Osmond DH, George SR, Liew CC (March 1994). "The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations". Brain Res. Mol. Brain Res. 22 (1-4): 173–85. doi:10.1016/0169-328X(94)90045-0. PMID 8015377. 
  3. ^ Irvine M, Huima T, Prince AM, Lustigman S (May 1994). "Identification and characterization of an Onchocerca volvulus cDNA clone encoding a highly immunogenic calponin-like protein". Mol. Biochem. Parasitol. 65 (1): 135–46. doi:10.1016/0166-6851(94)90122-8. PMID 7935620. 

This article incorporates text from the public domain Pfam and InterPro IPR000557