Calsenilin

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Kv channel interacting protein 3, calsenilin
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNIP3 ; CSEN; DREAM; KCHIP3
External IDs OMIM604662 MGI1929258 HomoloGene8382 GeneCards: KCNIP3 Gene
Orthologs
Species Human Mouse
Entrez 30818 56461
Ensembl ENSG00000115041 ENSMUSG00000079056
UniProt Q9Y2W7 Q9QXT8
RefSeq (mRNA) NM_001034914 NM_001111331
RefSeq (protein) NP_001030086 NP_001104801
Location (UCSC) Chr 2:
95.96 – 96.05 Mb
Chr 2:
127.46 – 127.52 Mb
PubMed search [1] [2]

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.[1][2][3]

Function[edit]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins.[4][5] Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.[3]

Interactions[edit]

Calsenilin has been shown to interact with PSEN1[1][6] and PSEN2.[1][7]

See also[edit]


References[edit]

  1. ^ a b c Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE et al. (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. 
  2. ^ Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature 398 (6722): 80–4. doi:10.1038/18044. PMID 10078534. 
  3. ^ a b "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin". 
  4. ^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005. 
  5. ^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. 
  6. ^ Kashiwa A, Yoshida H, Lee S, Paladino T, Liu Y, Chen Q et al. (July 2000). "Isolation and characterization of novel presenilin binding protein". J. Neurochem. 75 (1): 109–16. doi:10.1046/j.1471-4159.2000.0750109.x. PMID 10854253. 
  7. ^ Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C et al. (June 2001). "Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2". J. Biol. Chem. 276 (22): 19197–204. doi:10.1074/jbc.M008597200. PMID 11278424. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.