Calx-beta motif

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PDB 2fws EBI.jpg
first ca2+ binding domain of the na,ca-exchanger (ncx1)
Symbol Calx-beta
Pfam PF03160
InterPro IPR003644

In molecular biology, the calx-beta motif is a protein motif which is present as a tandem repeat in the cytoplasmic domains of Calx sodium-calcium exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-beta motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in some cyanobacterial proteins. This motif contains a series of beta-strands and turns that form a self-contained beta-sheet.[1][2]


  1. ^ Schwarz EM, Benzer S (September 1997). "Calx, a Na-Ca exchanger gene of Drosophila melanogaster". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10249–54. doi:10.1073/pnas.94.19.10249. PMC 23348. PMID 9294196. 
  2. ^ Schwarz E, Benzer S (July 1999). "The recently reported NIbeta domain is already known as the Calx-beta motif". Trends Biochem. Sci. 24 (7): 260. doi:10.1016/S0968-0004(99)01422-X. PMID 10390612. 

This article incorporates text from the public domain Pfam and InterPro IPR003644