Born in London to a Swedish father and English mother, Arfwedson was brought up in Chelsea and attended the Francis Holland School as a day girl. She then studied Classics at the University of Edinburgh. There, she joined the theatre society, and gained parts in the stage plays: Sore Throats and A Slight Ache both directed by Thom Tuck; Skylight directed by Michael Sophocles; Private Lives directed by Frederic Wake-Walker; Bedroom Farce directed by Simon Yadoo; the speaker in the Vagina Monologues directed by Alice Russell.
Becoming a professional actress upon graduation, Arfwedson has since worked mainly in the theatre, including Portia in the Merchant of Venice, the first touring production of Festen, and the role of Evelyn in the Barons Court Theatre production of Neil LaBute's The Shape of Things directed by Ed Behrens.
Arfwedson's television roles have included parts in Law & Order: UK and Agatha Christie's Marple: Murder Is Easy. Her film roles have included playing Lady Charlotte in The Duchess, and playing Burt Reynolds' daughter in the British comedy film A Bunch of Amateurs.
In 2012, Arfwedson starred in a television commercial for travel website Secret Escapes. Follow-up adverts were also released in 2013. She played Sheriff Angela Carter in Wrong Turn 5: Bloodlines, and in 2013, appeared in the second episode of BBC Three sitcom Way to Go, before joining the cast of BBC One medical drama Holby City.
|2005||TV movie||A Waste of Shame||Lucie's maid|
|2007||TV movie||Sex, the City and Me||Tamara|
|2008||Film||The Duchess||Lady Charlotte|
|2008||TV movie||Agatha Christie's Marple||Rose Humbleby|
|2008||Film||A Bunch of Amateurs||Amanda Blackie|
|2009||Television||Minder||Henriette Phillips||Episode "The Art of the Matter"|
|2009||Television||Law & Order: UK||Laura Todd||Episode "Alesha"|
|2010||Television||Lewis||Scarlett Mortmaigne||Episode "The Dead of Winter"|
|2011||Television||Pete Versus Life||Helene||Episode "A Night at the Light Opera"|
|2012||Film||Wrong Turn 5: Bloodlines||Sheriff Angela|
|2012||Short||If it Looks like Love||Pippa||post production|
|2013||Television||Way to Go||Kelly||Episode 2 "The Business End of Things"|
|2013—||Television||Holby City||Zosia March|
|TBC||Television||Air Force One is Down||Irene||post production|
- Benita Adesuyan, What the doctor ordered: rising star Camilla Arfwedson is Holby's newest medic dated 8 September 2013 at express.co.uk, accessed 28 March 2014
- Lizzie Smith (18 November 2008). "Oops, did I fall out?". Daily Mail. Retrieved 2012-08-05.
- "Camilla Arfwedson". United Agents. Retrieved 2012-08-05.
- "Camilla Arfwedson". Side by Side. Retrieved 2012-08-05.
- "Secret Escapes Television Advert - February 2012". SecretEscapes.com. Retrieved 2012-08-05.