The Jesuit Order sent Father Costanzo to China; but the Portuguese prevented his entrance into that country.
Instead, his energy and calling were invested in Japan. He learned the Japanese language quickly; and he successfully encouraged converts in the region near the city of Sakai.
When all missionaries were banished from Japan, he went to Macau.
Despite the dangers involved in ignoring the Tokugawa shogunate's exclusionary laws (sakoku), he returned in 1621. Disguised as a soldier, he managed to elude capture until April 24, 1622 when he was arrested on the island of Hirado off the western coast of Kyushu.
He was condemned to death; and he was burned alive on September 15, 1622.