||This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. (January 2012)|
|Jmol-3D images||Image 1
|Molar mass||200.23 g mol−1|
|Melting point||183-187 °C|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
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Camphoric acid, C10H16O4 or in Latin form Acidum camphoricum, is a white crystallisable substance obtained from the oxidation of camphor, it exists in three optically different forms; dextrorotatory one is obtained by the oxidation of dextrorotatory camphor and used in pharmaceuticals.
Acidum camphoricum was studied and isolated for the first time by French pharmacist Nicolas Vauquelin in the early 19th century but it wasn't until September 1874 that Dutch chemist Jacobus H. van 't Hoff proposed the first suggestion for its molecular structure and optical properties. Haller and Blanc synthesized camphor from camphoric acid. In 1904, Finnish chemist Gustav Komppa became the first to succeed in manufacturing synthetic camphoric acid from diethyl oxalate and 3,3-dimethylpentanoic acid, and thus proving the structure of camphor.
Chemical properties and isolation
Camphoric acid may be prepared by oxidising camphor with nitric acid.
- "Acidum camphoricum". The British Pharmaceutical Codex. Retrieved September 4, 2005.
- "Camphoric acid". Science and Technology. Retrieved September 4, 2005.
- "Camphoric acid". Taiwan Tekho Camphor Co. Retrieved September 4, 2005.
- Jacobus Henricus van 't Hoff (1874). "A suggestion looking to the extension into space of the structural formulas at present used in chemistry. And a note upon the relation between the optical activity and the chemical constitution of organic compounds". Archives neerlandaises des sciences exactes et naturelles 9: 445–454.