Canakinumab

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Canakinumab ?
Monoclonal antibody
Type Whole antibody
Source Human
Target IL-1β
Clinical data
Trade names Ilaris
AHFS/Drugs.com Consumer Drug Information
Licence data EMA:Link, US FDA:link
Legal status
Routes intravenous, subcutaneous
Identifiers
CAS number 914613-48-2 N
ATC code L04AC08
DrugBank DB06168
UNII 37CQ2C7X93 YesY
ChEMBL CHEMBL1201834 N
Chemical data
Formula C6452H9958N1722O2010S42 
Mol. mass 145.2 kDa
 N (what is this?)  (verify)

Canakinumab (INN, trade name Ilaris, previously ACZ885)[1] is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.[2]

Canakinumab was approved for the treatment of cryopyrin-associated periodic syndromes (CAPS) by the U.S. Food and Drug Administration (FDA) on June 2009[3] and by the European Medicines Agency in October 2009.[4] CAPS is a spectrum of autoinflammatory syndromes including familial cold autoinflammatory syndrome, Muckle–Wells syndrome, and neonatal-onset multisystem inflammatory disease.

Canakinumab was being developed by Novartis for the treatment of rheumatoid arthritis but this trial was completed in October 2009.[5] Canakinumab is also in phase I clinical trials as a possible treatment for chronic obstructive pulmonary disease,[6] gout and coronary artery disease. In gout it may result in better outcomes than a low dose of a steroid but costs five thousand times more.[7]

References[edit]

  1. ^ Dhimolea, Eugen (2010). "Canakinumab". MAbs 2 (1): 3–13. doi:10.4161/mabs.2.1.10328. PMC 2828573. PMID 20065636. 
  2. ^ Lachmann, HJ; Kone-Paut I, Kuemmerle-Deschner JB et al. (4 June 2009). "Use of canakinumab in the cryopyrin-associated periodic syndrome". New Engl J Med 360 (23): 2416–25. doi:10.1056/NEJMoa0810787. PMID 19494217. 
  3. ^ "New biological therapy Ilaris approved in US to treat children and adults with CAPS, a serious life-long auto-inflammatory disease" (Press release). Novartis. 18 June 2009. Retrieved 28 July 2009. 
  4. ^ Wan, Yuet (29 October 2009). "Canakinumab (Ilaris) and rilonacept (Arcalyst) approved in EU for treatment of cryopyrin-associated periodic syndrome". National electronic Library for Medicines. Retrieved 14 April 2010. 
  5. ^ "clinicaltrials.gov, Identifier NCT00784628: Safety, Tolerability and Efficacy of ACZ885 (Canakinumab) in Patients With Active Rheumatoid Arthritis". Retrieved 2010-08-21. 
  6. ^ Yasothan U, Kar S (2008). "Therapies for COPD". Nat Rev Drug Discov 7 (4): 285. doi:10.1038/nrd2533. 
  7. ^ Sivera, F; Wechalekar, MD; Andrés, M; Buchbinder, R; Carmona, L (Sep 1, 2014). "Interleukin-1 inhibitors for acute gout.". The Cochrane database of systematic reviews 9: CD009993. PMID 25177840.