Candace Pert
| Candace Beebe Pert | |
|---|---|
| Born | 26 June 1946 |
| Nationality | American |
| Fields | Neuroscience |
| Institutions | National Institutes of Health Georgetown University |
| Known for | Opiate receptor |
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Candace Beebe Pert (born June 26, 1946) is an American neuroscientist and pharmacologist who discovered the opiate receptor, the cellular binding site for endorphins in the brain.
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[edit] History
In 1974 she earned a Ph.D. in pharmacology from Johns Hopkins University School of Medicine, where she worked in the laboratory of Solomon Snyder. Previously, she had completed her undergraduate studies in biology, cum laude, in 1970, from Bryn Mawr College in Pennsylvania. Pert conducted a National Institutes of Health Postdoctoral Fellowship with the Department of Pharmacology at the Johns Hopkins University School of Medicine from 1974-1975. She conducted research at the National Institute of Mental Health from 1975 to 1987. Pert is the author of Molecules of Emotion. She appeared as one of the experts in Bill Moyers 1993 PBS video production, "Healing and the Mind", and in the 2004 film What the #$*! Do We Know!?.
After 1975, Pert held a variety of research positions with the National Institute of Mental Health, and until 1987, served as Chief of the Section on Brain Biochemistry of the Clinical Neuroscience Branch of the NIMH. She then founded and directed a private biotech laboratory. Pert was a Research Professor in the Department of Physiology and Biophysics at Georgetown University School of Medicine in Washington, DC. Currently, she is with RAPID Pharmaceuticals.[1][2]
Pert is an internationally recognized pharmacologist who has published over 250 scientific articles on peptides and their receptors and the role of these neuropeptides in the immune system. Her earliest work as a researcher involved the discovery of opiate receptors and the actions of receptors. She has an international reputation in the field of neuropeptide and receptor pharmacology, and chemical neuroanatomy. Pert has also lectured worldwide on these and other subjects, including her theories on emotions and mind-body communication. Her popular book, "Molecules of Emotion: Why You Feel the Way You Feel", (Scribner, 1997) expounds on her research and theories. She was featured in "Washingtonian" magazine (December 2001) as one of Washington's fifty "Best and Brightest" individuals. She holds a number of patents for modified peptides in the treatment of psoriasis, Alzheimer's disease, chronic fatigue syndrome, stroke and head trauma. One of these, Peptide T, had been considered for the treatment of AIDS and neuroAIDS. The results of a placebo-controlled, three site, 200+ patient NIH-funded clinical trial which focused on neurocognitive improvements, was conducted between 1990 and 1995. The results showed that Peptide T was not significantly different from placebo on the study primary end points, tests of brain function. However Peptide T was associated with improved performance (memory and learning) in the subgroup of patients with more severe cognitive impairment.[3] A long-delayed analysis of antiviral effects from the NIH study showed peripheral viral load (combined plasma and serum) was significantly reduced in the DAPTA-treated group.[4] An eleven person study for Peptide T effects on cellular viral load showed reductions in infected monocyte reservoir to undetectable levels in most of the patients.[5]
[edit] Books
- Molecules Of Emotion: The Science Between Mind-Body Medicine Scribner (1999), ISBN 0-684-84634-9
- Everything You Need to Know to Feel Go(o)d, with Nancy Marriott, Hay House, Inc. (2006), ISBN 1-4019-1059-9
[edit] Events
- Pert was honored by the New York Open Center on November 7, 2006 for her "leadership across the bridge between science and heart."[cite this quote]
- Pert received the first time award of the Theophrastus Paracelsus Foundation in Holistic Medicine for her pioneering work in the area of Psychoneuroimmunology (St Gallen, Switzerland) on April 12, 2008.
[edit] Other
In 2004, Pert was an interview partner in the documentary film What the Bleep Do We Know!? where she appeared several times.
[edit] References
- ^ RapidPharmaceuticals rapidpharma.com
- ^ Candace Pert candacepert.com
- ^ Heseltine PN, Goodkin K, Atkinson JH, et al. (January 1998). "Randomized double-blind placebo-controlled trial of peptide T for HIV-associated cognitive impairment". Archives of Neurology 55 (1): 41–51. doi:10.1001/archneur.55.1.41. PMID 9443710.
- ^ Goodkin K, Vitiello B, Lyman WD, et al. (June 2006). "Cerebrospinal and peripheral human immunodeficiency virus type 1 load in a multisite, randomized, double-blind, placebo-controlled trial of D-Ala1-peptide T-amide for HIV-1-associated cognitive-motor impairment". Journal of Neurovirology 12 (3): 178–89. doi:10.1080/13550280600827344. PMID 16877299.
- ^ Polianova MT, Ruscetti FW, Pert CB, et al. (July 2003). "Antiviral and immunological benefits in HIV patients receiving intranasal peptide T (DAPTA)". Peptides 24 (7): 1093–8. doi:10.1016/S0196-9781(03)00176-1. PMID 14499289.
