Cannabichromene

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Cannabichromene
Cannabichromene-skeletal.svg
Identifiers
CAS number 20675-51-8 YesY
PubChem 30219
ChemSpider 28064 N
ChEMBL CHEMBL422704 N
Jmol-3D images Image 1
Properties
Molecular formula C21H30O2
Molar mass 314.46 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Cannabichromene (abbreviated as CBC) is a cannabinoid found in the cannabis plant. It bears structural similarity to the other natural cannabinoids, including tetrahydrocannabinol, tetrahydrocannabivarin, cannabidiol, and cannabinol, among others. Evidence has suggested that it may play a role in the anti-inflammatory and anti-viral effects of cannabis, and may contribute to the overall analgesic effects of medical cannabis. However, more research into the compound may be needed before any definite medical effects can be verified.[1]

CBC has two stereoisomers. It is not scheduled by the Convention on Psychotropic Substances. CBC is non-psychotropic.[2]

Medical uses[edit]

A 2011 study in the British Journal of Pharmacology found that CBD and CBC stimulated descending pathways of antinociception and caused analgesia by interacting with several target proteins involved in nociceptive control.[2] A study in Neurochemistry International suggested that cannabichromene might stimulate the growth of brain cells by stimulating adult neural stem progenitor cells (NSPCs). The study said "our results suggest that CBC raises the viability of NSPCs while inhibiting their differentiation into astroglia, possibly through up-regulation of ATP and adenosine signalling.[3]

References[edit]

  1. ^ Gaoni, Y.; Mechoulam, R. (1966). "Cannabichromene, a new active principle in hashish". Chemical Communications 1: 20–1. doi:10.1039/C19660000020. 
  2. ^ a b Maione, Sabatino; Piscitelli, Fabiana; Gatta, Luisa; Vita, Daniela; De Petrocellis, Luciano; Palazzo, Enza; De Novellis, Vito; Di Marzo, Vincenzo (2011). "Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action". British Journal of Pharmacology 162 (3): 584–96. doi:10.1111/j.1476-5381.2010.01063.x. PMID 20942863. 
  3. ^ Shinjyo, Noriko; Di Marzo, Vincenzo (2013). "The effect of cannabichromene on adult neural stem/progenitor cells". Neurochemistry International 63 (5): 432–7. doi:10.1016/j.neuint.2013.08.002. PMID 23941747.