Cannabigerol

Cannabigerol
Systematic (IUPAC) name
	2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	25654-31-3
ATC code	None
PubChem	CID 5315659
ChemSpider	4474921
ChEMBL	CHEMBL497318
Chemical data
Formula	C21H32O2
Mol. mass	316.48 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+ ; Key:QXACEHWTBCFNSA-SFQUDFHCSA-N ;
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Cannabigerol (CBG) is a non-psychoactive cannabinoid found in the Cannabis genus of plants. Cannabigerol is found in higher concentrations in hemp rather than in varieties of Cannabis with high THC content (the kind used as a drug).^{[citation needed]}

Cannabigerol has been found to act as a high affinity α₂-adrenergic receptor agonist, moderate affinity 5-HT_1A receptor antagonist, and low affinity CB₁ receptor antagonist.^[1] It also binds to the CB₂ receptor, but whether it acts as an agonist or antagonist at this site is unknown.^[1]

Cannabigerol has been shown to relieve intraoccular pressure, which may be of benefit in the treatment of glaucoma.^[2]^[3]

[edit] See also

[edit] References

^ ^a ^b Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee R (December 2009). "Evidence that the plant cannabinoid cannabigerol is a highly potent alpha(2)-adrenoceptor agonist and moderately potent 5HT receptor antagonist". British Journal of Pharmacology 159 (1): 129–141. doi:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2823359.
^ Colasanti, B. (1990). "A comparison of the ocular and central effects of delta 9-tetrahydrocannabinol and cannabigerol". Journal of ocular pharmacology 6 (4): 259–269. PMID 1965836. edit
^ Colasanti, B.; Craig, C.; Allara, R. (1984). "Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol". Experimental eye research 39 (3): 251–259. PMID 6499952. edit

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[pmid20002104-0] Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee R (December 2009). "Evidence that the plant cannabinoid cannabigerol is a highly potent alpha(2)-adrenoceptor agonist and moderately potent 5HT receptor antagonist". British Journal of Pharmacology 159 (1): 129–141. doi:10.1111/j.1476-5381.2009.00515.x. PMC 2823359. PMID 20002104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2823359.

[1] Colasanti, B. (1990). "A comparison of the ocular and central effects of delta 9-tetrahydrocannabinol and cannabigerol". Journal of ocular pharmacology 6 (4): 259–269. PMID 1965836. edit

[2] Colasanti, B.; Craig, C.; Allara, R. (1984). "Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol". Experimental eye research 39 (3): 251–259. PMID 6499952. edit

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Cannabigerol

[edit] See also

[edit] References

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