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This image shows the structures of Cap32/34 superposed onto CapZ (in green) over the Cα positions of the entire CP molecules.[1]

In molecular biology CapZ, also known as CAPZ; CAZ1 and CAPPA1, is a protein that caps the barbed (plus) end of actin filaments in muscle cells. It is located in the Z band of the muscle sarcomere.

This protein helps to stabilize the actin filaments protecting it from assembly. The activity regulation of this protein can be done by other regulatory proteins that bind to the actin filaments blocking the CapZ, hence allowing assembly.[2]

A modest reduction in cardiac CapZ protein protects hearts against acute ischemia-reperfusion injury.[3]


  1. ^ Eckert, C.; Goretzki, A.; Faberova, M.; Kollmar, M. (2012). "Conservation and divergence between cytoplasmic and muscle-specific actin capping proteins: Insights from the crystal structure of cytoplasmic Cap32/34 from Dictyostelium discoideum". BMC Structural Biology 12: 12. doi:10.1186/1472-6807-12-12. PMC 3472329. PMID 22657106.  edit
  2. ^ Lodish, Harvey; Berk, Arnold; Kaiser, Chris; Krieger, Monty; Bretscher, Antony; Ploegh, Hidde; Amon, Angelika; Scott, Matthew. Molecular Cell Biology (7th ed.). p. 783. ISBN 9781429234139. 
  3. ^ Yang, Feng Hua; Pyle, WG (2 Dec 2011). "Reduced cardiac CapZ protein protects hearts against acute ischemia-reperfusion injury and enhances preconditioning". Journal of Molecular and Cellular Cardiology epub (3): 761–72. doi:10.1016/j.yjmcc.2011.11.013. PMID 22155006. 


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