|Systematic (IUPAC) name|
|Pregnancy cat.||D (US)|
|Legal status||POM (UK) ℞-only (US)|
|Metabolism||Hepatic—by CYP3A4, to active epoxide form (carbamazepine-10,11 epoxide)|
|Half-life||25–65 hours (after several doses 12–17 hours)|
|Excretion||2–3% excreted unchanged in urine|
|Mol. mass||236.269 g/mol|
| (what is this?)
Carbamazepine (CBZ) (Tegretol, Equetro) is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. It is also used off-label for a variety of indications, including attention-deficit hyperactivity disorder (ADHD), schizophrenia, phantom limb syndrome, complex regional pain syndrome, paroxysmal extreme pain disorder, neuromyotonia, intermittent explosive disorder, borderline personality disorder, Myotonia congenita and post-traumatic stress disorder.
Medical uses 
Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It may be used as a second line treatment for bipolar disorder and along with antipsychotic agents in schizophrenia.
In the United States, the FDA-approved indications are epilepsy (including partial seizures and tonic-clonic seizures), trigeminal neuralgia, and manic and mixed episodes of bipolar I disorder. Although data are still lacking, carbamazepine appears to be as effective and safe as lithium for the treatment of bipolar disorder, both in the acute and maintenance phase.
Adverse effects 
Common adverse effects may include drowsiness, headaches and migraines, motor coordination impairment, and/or upset stomach. Carbamazepine preparations typically greatly decrease a person's alcohol tolerance.
Less common side-effects may include cardiac arrhythmias, blurry or double vision and/or the temporary loss of blood cells or platelets and in rare cases can cause aplastic anemia. With normal use, small reductions in white cell count and serum sodium are common; however, in rare cases, the loss of platelets may become life-threatening. In this case a doctor may recommend frequent blood tests during the first few months of use, followed by three to four tests per year for established patients. Additionally, carbamazepine may possibly exacerbate preexisting cases of hypothyroidism, so yearly thyroid function tests are advisable for persons taking the drug.
There are also rare reports of an auditory side-effect for carbamazepine use, whereby patients perceive sounds about a semitone lower than previously. Thus, middle C would be heard as the note B3 just below it, and so on. The inverse effect (that is, notes sounding higher) has also been recorded. This unusual side-effect is usually not noticed by most people, and quickly disappears after the person stops taking carbamazepine.
Oxcarbazepine, a derivative of carbamazepine, reportedly has fewer and less serious side-effects.
Carbamazepine may aggravate juvenile myoclonic epilepsy, so it is important to uncover any history of jerking, especially in the morning, before starting the drug. It may also aggravate other types of generalized seizure disorder, particularly absence seizures.
The FDA informed health care professionals that dangerous or even fatal skin reactions (Stevens–Johnson syndrome and toxic epidermal necrolysis), that can be caused by carbamazepine therapy, are significantly more common in patients with a particular human leukocyte antigen (HLA) allele, HLA-B*1502. This allele occurs almost exclusively in patients with ancestry across broad areas of Asia, including South Asian Indians. In Europeans a large proportion of sensitivity is associated with HLA-B58. Researchers have also identified another genetic variant, HLA-A*3101 which has been shown to be a strong predictor of both mild and severe adverse reactions to carbamazepine among Japanese and Europeans.
Associated birth defects 
If taken by a pregnant mother, Carbamazepine can cause birth defects that include: cardiovascular and urinary tract anomalies, cleft palate, fingernail hypoplasia, microcephaly, developmental delays, and intrauterine growth restrictions.
Carbamazepine has a potential for drug interactions; caution should be used in combining other medicines with it, including other antiepileptics and mood stabilizers. Lower levels of carbamazepine are seen when administrated with phenobarbital, phenytoin (Dilantin), or primidone (Mysoline). Carbamazepine, as a CYP450 inducer, may increase clearance of many drugs, decreasing their blood levels. Drugs that are more rapidly metabolized with carbamazepine include warfarin (Coumadin), lamotrigine (Lamictal), phenytoin (Dilantin), theophylline, and valproic acid (Depakote, Depakote ER, Depakene, Depacon). Drugs that decrease the metabolism of carbamazepine or otherwise increase its levels include erythromycin, cimetidine (Tagamet), propoxyphene (Darvon), and calcium channel blockers. Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies. As a drug that induces cytochrome P450 enzymes, it accelerates elimination of many benzodiazepines and decreases their action.
Valproic acid and valnoctamide both inhibit microsomal epoxide hydrolase (mEH), the enzyme responsible for the breakdown of carbamazepine-10,11 epoxide into inactive metabolites. By inhibiting mEH, valproic acid and valnoctamide cause a buildup of the active metabolite, prolonging the effects of carbamazepine and delaying its excretion.
Grapefruit juice raises the bioavailability of carbamazepine by inhibiting CYP3A4 enzymes in the gut wall and in the liver.
Environmental impact 
Carbamazepine can enter the environment through discharge of wastewater, and has also been shown to persist and accumulate in the organic components of soil and sludge. As carbamazepine is an emerging contaminant, the effects of its bioaccumulation on other living creatures and plants are not well-understood.
cabamazine is slowy but well absorbed after oral administration.its plasma half life is about 30h when it is givn as single dose,but it is a strong inducer of hepatic enzymes,and the plasma halflife shortens to about 15h when it is given repeteadly.some of its metabolites have antiepileptic properties.A slow-release pepaation is used for patients who experience transit side effects coinciding with plasma concentration peaks following oral dosing.
Mechanism of action 
The mechanism of action of carbamazepine and its derivatives is relatively well-understood. Carbamazepine stabilizes the inactivated state of Voltage-gated sodium channels, making fewer of these channels available to subsequently open. This leaves the affected cells less excitable until the drug dissociates. Carbamazepine has also been shown to potentiate GABA receptors made up of alpha1, beta2, gamma2 subunits.such as neuopathic pain and manic-depessive illness
Carbamazepine was discovered by chemist Walter Schindler at J.R. Geigy AG (now part of Novartis) in Basel, Switzerland, in 1953. Schindler then synthesized the drug in 1960, before its anti-epileptic properties had been discovered.
Carbamazepine was first marketed as a drug to treat trigeminal neuralgia (formerly known as tic douloureux) in 1962. It has been used as an anticonvulsant and antiepileptic in the UK since 1965, and has been approved in the US since 1974.
In 1971, Drs. Takezaki and Hanaoka first used carbamazepine to control mania in patients refractory to antipsychotics (lithium was not available in Japan at that time). Dr. Okuma, working independently, did the same thing with success. As they were also epileptologists, they had some familiarity with the anti-aggression effects of this drug. Carbamazepine would be studied for bipolar disorder throughout the 1970s.
Brand names 
Carbamazepine has been sold under the names Biston (Czech), Calepsin, Carbatrol, Epitol, Equetro, Finlepsin, Sirtal, Stazepine, Telesmin, Tegretol, EPITAB XR(of Werrick Pakistan') Teril, Timonil, Trimonil, Epimaz, Carbama/Carbamaze (New Zealand), Amizepin (Poland), Carzine (Kolkata), Mazetol, Tegrital, Tegrita, Zeptol (India), Karbapin (Serbia), Hermolepsin (Sweden), Degranol (South Africa), and Tegretal (Chile, Germany).
See also 
Schindler, W.; 1960, U.S. Patent 2,948,718.
Carbamazepine is a dibenzazepine.
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- Degranol Tablets[dead link]
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|Wikimedia Commons has media related to: Carbamazepine|
- Carbatrol website
- Equetro website
- Carbamazepine Pharmacokinetics - PubPK
- TA warning
- Carbamazepine overview from PsychEducation.org
- Extensive review of the effects of carbamazepine in pregnancy and breastfeeding (free full text with registration)
- U.S. Patent 2,948,718, August 1960