Carbamoyl phosphate

Carbamoyl phosphate
IUPAC name (Carbamoyloxy)phosphonic acid
Identifiers
CAS number	590-55-6
PubChem	278
MeSH	Carbamoyl+phosphate
Jmol-3D images	Image 1
SMILES C(=O)(N)OP(=O)(O)O
Properties
Molecular formula	CH2NO5P2-
Molar mass	141.020 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals it is an intermediary metabolite participating in the nitrogen disposal through in the urea cycle and the synthesis of pyrimidines.

It is produced from bicarbonate, ammonia (derived from glutamate), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

• HCO₃⁻ + ATP → ADP + HO–C(O)–OPO₃²⁻ (carboxyl phosphate)
• HO–C(O)–OPO₃²⁻ + NH₃ + OH⁻ → HPO₄²⁻ + ⁻O–C(O)NH₂ + H₂O
• ⁻O–C(O)NH₂ + ATP → ADP + H₂NC(O)OPO₃²⁻

See also

• Ornithine transcarbamylase

References

• Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York.