Carbamoyl phosphate

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Carbamoyl phosphate
Structural formula
Ball-and-stick model
Identifiers
CAS number 590-55-6 YesY
PubChem 278
ChemSpider 272 N
KEGG C00169 N
MeSH Carbamoyl+phosphate
ChEBI CHEBI:17672 N
ChEMBL CHEMBL369105 N
Jmol-3D images Image 1
Properties
Molecular formula CH2NO5P2−
Molar mass 141.020 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals it is an intermediary metabolite participating in the nitrogen disposal through in the urea cycle and the synthesis of pyrimidines.

Production[edit]

It is produced from bicarbonate, ammonia (derived from glutamine), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

  • HCO3 + ATP → ADP + HO–C(O)–OPO32− (carboxyl phosphate)
  • HO–C(O)–OPO32− + NH3 + OH → HPO42− + O–C(O)NH2 + H2O
  • O–C(O)NH2 + ATP → ADP + H2NC(O)OPO32−

See also[edit]

References[edit]

  • Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York.