|Systematic (IUPAC) name|
|Pregnancy cat.||B (US) Passes into breast milk|
|Legal status||℞-only (US)|
|Bioavailability||30 to 40%|
|Protein binding||30 to 60%|
|Excretion||Renal (30 to 40%)|
|Mol. mass||378.401 g/mol|
| (what is this?)
Carbenicillin is a bacteriolytic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It was discovered by scientists at Beecham and marketed as Pyopen. It has Gram-negative coverage which includes Pseudomonas aeruginosa but limited Gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes, although they are more resistant than ampicillin to degradation. Carbenicillin is also more stable at lower pH than ampicillin.
The antibiotic is very soluble in water and is acid-labile. A typical lab working concentration is 100 µg per ml.
It is a semi-synthetic analogue of the naturally occurring benzyl-penicillin. Carbenicillin at high doses can cause bleeding. Use of carbenicillin can cause hypokalemia by promoting potassium loss at the distal convoluted tubule of the kidney.
In molecular biology, carbenicillin may be preferred as a selecting agent (see Plasmid stabilisation technology) because its breakdown results in byproducts with a lower toxicity than analogous antibiotics like ampicillin. Carbenicillin is more stable than ampicillin and results in less satellite colonies on selection plates. However, in most situations this is not a significant problem so ampicillin is sometimes used due to its lower cost.
Spectrum of bacterial susceptibility and resistance
Most of the bacteria like Burkholderia,Escherichia coli,Pseudomonas and Salmonella have developed resistance toward Carbenicillin. Some of Staphylococcus developed resistance to Carbenicillin and some of them are susceptible to it. For the detailed information about the MIC of Carbenicillin, please refer to Carbenicillin Susceptibility and Resistance data sheet.
- Basker MJ, Comber KR, Sutherland R, Valler GH (1977). "Carfecillin: antibacterial activity in vitro and in vivo". Chemotherapy 23 (6): 424–35. doi:10.1159/000222012. PMID 21771.
- Pawełczyk E, Zajac M, Knitter B, Mikołajczak P (October 1981). "Kinetics of drug decomposition. Part 66. Kinetics of the hydrolysis of carphecillin in aqueous solution". Polish journal of pharmacology and pharmacy 33 (3): 373–86. PMID 7322950.
- "Carbenicillin Susceptibility and Resistance data". Retrieved 14 July 2013.
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