Carbonic anhydrase II

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"CA II" redirects here. For the spectral features of calcium, see Calcium § H_and_K_lines.
Carbonic anhydrase II
Protein CA2 PDB 12ca.png
PDB rendering based on 12ca[1].
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CA2 ; CA-II; CAC; CAII; Car2; HEL-76
External IDs OMIM611492 MGI88269 HomoloGene37256 ChEMBL: 205 GeneCards: CA2 Gene
EC number
RNA expression pattern
PBB GE CA2 209301 at tn.png
More reference expression data
Species Human Mouse
Entrez 760 12349
Ensembl ENSG00000104267 ENSMUSG00000027562
UniProt P00918 P00920
RefSeq (mRNA) NM_000067 NM_009801
RefSeq (protein) NP_000058 NP_033931
Location (UCSC) Chr 8:
86.38 – 86.39 Mb
Chr 3:
14.89 – 14.9 Mb
PubMed search [1] [2]

Carbonic anhydrase II (gene name CA2), is one of fourteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. [2]


Carbonic anhydrase II has been shown to interact with Band 3[3][4][5][6] and Sodium-hydrogen antiporter 1.[7]


  1. ^ Nair, S. K.; Calderone, T. L.; Christianson, D. W.; Fierke, C. A. (1991). "Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121". The Journal of biological chemistry 266 (26): 17320–17325. PMID 1910042.  edit
  2. ^ "Entrez Gene: CA2 carbonic anhydrase II". 
  3. ^ Sterling, D; Reithmeier R A; Casey J R (December 2001). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers". J. Biol. Chem. (United States) 276 (51): 47886–94. doi:10.1074/jbc.M105959200. ISSN 0021-9258. PMID 11606574. 
  4. ^ Vince, J W; Reithmeier R A (October 1998). "Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger". J. Biol. Chem. (UNITED STATES) 273 (43): 28430–7. doi:10.1074/jbc.273.43.28430. ISSN 0021-9258. PMID 9774471. 
  5. ^ Vince, J W; Carlsson U; Reithmeier R A (November 2000). "Localization of the Cl-/HCO3- anion exchanger binding site to the amino-terminal region of carbonic anhydrase II". Biochemistry (UNITED STATES) 39 (44): 13344–9. doi:10.1021/bi0015111. ISSN 0006-2960. PMID 11063570. 
  6. ^ Vince, J W; Reithmeier R A (May 2000). "Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1". Biochemistry (UNITED STATES) 39 (18): 5527–33. doi:10.1021/bi992564p. ISSN 0006-2960. PMID 10820026. 
  7. ^ Li, Xiuju; Alvarez Bernardo; Casey Joseph R; Reithmeier Reinhart A F; Fliegel Larry (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". J. Biol. Chem. (United States) 277 (39): 36085–91. doi:10.1074/jbc.M111952200. ISSN 0021-9258. PMID 12138085. 

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