Carbonic anhydrase III, muscle specific

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Carbonic anhydrase III, muscle specific
PBB Protein CA3 image.jpg
PDB rendering based on 1flj.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CA3 ; CAIII; Car3
External IDs OMIM114750 MGI88270 HomoloGene31298 ChEMBL: 2885 GeneCards: CA3 Gene
EC number
RNA expression pattern
PBB GE CA3 204865 at tn.png
More reference expression data
Species Human Mouse
Entrez 761 12350
Ensembl ENSG00000164879 ENSMUSG00000027559
UniProt P07451 P16015
RefSeq (mRNA) NM_005181 NM_007606
RefSeq (protein) NP_005172 NP_031632
Location (UCSC) Chr 8:
86.29 – 86.36 Mb
Chr 3:
14.86 – 14.87 Mb
PubMed search [1] [2]

Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.[1]

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue-specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. CA3 is insufficient in muscles of Myasthenia Gravis patients.[2] A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. Autoantibodies to CA3 have been found to be significantly higher in patients with rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.[3] The gene spans 10.3 kb and contains seven exons and six introns.[4]


  1. ^ Shima K, Tashiro K, Hibi N, Tsukada Y, Hirai H (Jun 1983). "Carbonic anhydrase-III immunohistochemical localization in human skeletal muscle". Acta Neuropathol 59 (3): 237–9. doi:10.1007/BF00703210. PMID 6221502. 
  2. ^ Du AL, Ren HM, Lu CZ, Tu JL, Xu CF, Sun YA (Mar 2009). "Carbonic anhydrase III is insufficient in muscles of myasthenia gravis patients". Autoimmunity 42 (3): 209–15. doi:10.1080/08916930802668610. PMID 19301202. 
  3. ^ Liu C, Wei Y, Wang J, Pi L, Huang J, Wang P (Sep 2012). "Carbonic anhydrases III and IV autoantibodies in rheumatoid arthritis, systemic lupus erythematosus, diabetes, hypertensive renal disease, and heart failure". Clin Dev Immunol 2012: 354594. doi:10.1155/2012/354594. PMC 3461255. PMID 23049597. 
  4. ^ "Entrez Gene: CA3 carbonic anhydrase III, muscle specific". 

Further reading[edit]