Carbonic anhydrase 4

From Wikipedia, the free encyclopedia
  (Redirected from Carbonic anhydrase IV)
Jump to: navigation, search
Carbonic anhydrase IV
Protein CA4 PDB 1znc.png
PDB rendering based on 1znc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CA4 ; CAIV; Car4; RP17
External IDs OMIM114760 MGI1096574 HomoloGene20183 IUPHAR: 2599 ChEMBL: 3729 GeneCards: CA4 Gene
EC number
RNA expression pattern
PBB GE CA4 206209 s at tn.png
PBB GE CA4 206208 at tn.png
More reference expression data
Species Human Mouse
Entrez 762 12351
Ensembl ENSG00000167434 ENSMUSG00000000805
UniProt P22748 Q64444
RefSeq (mRNA) NM_000717 NM_007607
RefSeq (protein) NP_000708 NP_031633
Location (UCSC) Chr 17:
58.23 – 58.25 Mb
Chr 11:
84.96 – 84.97 Mb
PubMed search [1] [2]

Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene.[1][2]


Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.[2]


CA4 has been shown to interact with Band 3.[3]


  1. ^ Okuyama T, Batanian JR, Sly WS (Aug 1993). "Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q". Genomics 16 (3): 678–84. doi:10.1006/geno.1993.1247. PMID 8325641. 
  2. ^ a b "Entrez Gene: CA4 carbonic anhydrase IV". 
  3. ^ Sterling D, Alvarez BV, Casey JR (Jul 2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV". J. Biol. Chem. 277 (28): 25239–46. doi:10.1074/jbc.M202562200. PMID 11994299. 

Further reading[edit]

External links[edit]