Carbonic anhydrase 7

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Carbonic anhydrase VII
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CA7 ; CAVII
External IDs OMIM114770 MGI103100 HomoloGene55875 IUPHAR: 2749 ChEMBL: 2326 GeneCards: CA7 Gene
EC number
RNA expression pattern
PBB GE CA7 207504 at tn.png
More reference expression data
Species Human Mouse
Entrez 766 12354
Ensembl ENSG00000168748 ENSMUSG00000031883
UniProt P43166 Q9ERQ8
RefSeq (mRNA) NM_001014435 NM_001301164
RefSeq (protein) NP_001014435 NP_001288093
Location (UCSC) Chr 16:
66.88 – 66.89 Mb
Chr 8:
104.53 – 104.55 Mb
PubMed search [1] [2]

Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.[1][2]


Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.[2]


  1. ^ Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Dec 1991). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16". Genomics 11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. PMID 1783392. 
  2. ^ a b "Entrez Gene: CA7 carbonic anhydrase VII". 

Further reading[edit]