Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.
^Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Dec 1991). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16". Genomics11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. PMID1783392.
Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J et al. (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID10493829.
Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A et al. (Feb 2005). "Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides". Bioorganic & Medicinal Chemistry Letters15 (4): 971–6. doi:10.1016/j.bmcl.2004.12.052. PMID15686895.