Carboprost

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Carboprost
Carboprost.svg
Systematic (IUPAC) name
(5Z,9α,11α,13E,15S)-9,11,15-trihydroxy-15- methylprosta-5,13-dien-1-oic acid
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a600042
Pregnancy cat.
  • c
Legal status
  • Prescription only
Routes Intravenous
Identifiers
CAS number 58551-69-2 YesY
ATC code G02AD04
PubChem CID 5281075
DrugBank DB00429
ChemSpider 4444532 YesY
UNII U4526F86FJ YesY
ChEMBL CHEMBL1237122 N
Chemical data
Formula C21H36O5 
Mol. mass 368.508 g/mol
 N (what is this?)  (verify)

Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF (specifically, it is 15-methyl-PGF) with oxytocic properties.

Carboprost induces contractions and can trigger abortion in early pregnancy. It also reduces postpartum bleeding.

Indication[edit]

Used in postpartum hemorrhage caused by uterine atony not controlled by other methods.
Unlabeled use:

  • Hemorrhagic Cystitis
  • PID

Contraindication[edit]

Contraindicated in severe cardiovascular, renal, and hepatic disease, also contraindicated in Pelvic Inflammatory Disease. Exert caution in asthmatic patients.

Precautions[edit]

  • asthma
  • anemia
  • jaundice
  • diabetes mellitus
  • seizure disorders
  • past uterine surgery

Adverse Effects[edit]

  • diarrhea (most common, may be sudden in onset)
  • fever
  • chills
  • nausea/vomiting

References[edit]

External links[edit]

  • Carboprost at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Indman P (2004). "Use of carboprost to facilitate hysteroscopic resection of submucous myomas". J Am Assoc Gynecol Laparosc 11 (1): 68–72. doi:10.1016/S1074-3804(05)60014-X. PMID 15104835. 
  • Vukelić J (2001). "Second trimester pregnancy termination in primigravidas by double application of dinoprostone gel and intramuscular administration of carboprost tromethamine". Med Pregl 54 (1–2): 11–6. PMID 11436877. 
  • Ippoliti C, Przepiorka D, Mehra R, Neumann J, Wood J, Claxton D, Gajewski J, Khouri I, van Besien K, Andersson B (1995). "Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation". Urology 46 (6): 811–5. doi:10.1016/S0090-4295(99)80349-5. PMID 7502421.