Carboxyglutamic acid

Carboxyglutamic acid
IUPAC name 3-Aminopropane-1,1,3-tricarboxylic acid
Other names γ-Carboxyglutamate
Identifiers
CAS number	53445-96-8
PubChem	40772
ChemSpider	37241
Jmol-3D images	Image 1
SMILES O=C(O)C(C(=O)O)CC(N)C(=O)O
InChI InChI=1/C6H9NO6/c7-3(6(12)13)1-2(4(8)9)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)(H,12,13) Key: UHBYWPGGCSDKFX-UHFFFAOYAH
Properties
Molecular formula	C6H9NO6
Molar mass	191.14 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Carboxyglutamic acid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found, for example, in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade, Vitamin K is required to introduce gamma-carboxylation of clotting factors II, VII, IX, and X.

See also

• Gamma-glutamyl carboxylase