Mucoepidermoid carcinoma
| Mucoepidermoid carcinoma | |
|---|---|
| Classification and external resources | |
 Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain. |
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| ICD-O: | 8430/3 |
| OMIM | 607536 |
| MeSH | C04.557.470.200.025.340 |
Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, as bronchi, lacrimal sac [1] and thyroid.
Mucicarmine staining is one stain used by pathologist for detection.[2]
Contents |
[edit] Epidemiology
Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]
[edit] Clinical Features
Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.
[edit] Histology
This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.
[edit] Molecular biology
Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749.
[edit] Prognosis
Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.
[edit] Additional images
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Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. H & E stain.
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Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. The same lesion as shown in a filename "Mucoepidermoid carcinoma (2) HE stain.jpg". H & E stain.
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Histopathologic image of mucoepidermoid carcinoma. Postoperative recurrence of the submandibular tumor. Alcian blue-PAS stain.
_HE_stain.jpg)
_HE_stain.jpg)
_AB-PAS_stain.jpg)
[edit] References
- ^ Elsevier Article Locator
- ^ Modern Pathology - Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of Nine Cases
- ^ "Melnick M., Sedghizadeh P. P., Allen C. M., Jaskoll T.". Experimental and Molecular Pathology. 10 November 2011. doi:10.1016/j.yexmp.2011.10.011. PMID 22101257. http://www.sciencedirect.com/science/article/pii/S0014480011001869.
[edit] External links
- -489684982 at GPnotebook
- Overview at usc.edu
- Slide at jhu.edu
- mucoepidermoid carcinoma at humpath.com
- salivary mucoepidermoid carcinoma images at humpath.com
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