As a college student, Cheffers became interested in officiating through his father, and decided to work intramural sports to make additional income. Enjoying the experience of student sports, he sought assistance from his father to officiate high school football games to begin a career. Starting in 1980, he worked several high school playoff games, and two high school championship games. By 1995, Cheffers began officiating in the Pac-10 where he worked for five seasons before being hired by the NFL. During this time, he also worked in the Western Athletic Conference.
Since entering the NFL, Cheffers has worked as a side judge, most recently on the crew headed by referee Larry Nemmers. Cheffers was promoted to referee (crew chief) beginning with the 2008 NFL season following the retirement of Nemmers and referee Gerald Austin.
In his promotion to referee, NFL officiating director Mike Pereira said of Cheffers, "Carl has been extremely successful on the field as a side judge. He is very knowledgeable of the rules, a good rules guy. Strong presence. He was part of Larry Nemmers' crew and he was clearly a crew leader. When we first saw Carl, we saw referee experience from him even though he had refereed basically at the small-college level."
Cheffers' 2013 NFL officiating crew consists of umpire Undrey Wash, head linesman Kent Payne, line judge Tom Symonette, field judge Jeff Lamberth, side judge Laird Hayes and back judge Todd Prukop.
- "Carl Cheffers, officiating among NFL and NFL Europa". National Football League Italy. 2006-12-03. Retrieved 2008-04-27.
- "Carl Cheffers - NFL". Football Official's Camp. Retrieved 2008-04-27.
- Sando, Mike (2008-04-01). "NFL promotes Cheffers, Riveron to referee". ESPN. Retrieved 2008-04-28.
- 2013 NFL officiating crews