Carnitine palmitoyltransferase II

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Carnitine palmitoyltransferase 2
Identifiers
Symbols CPT2 ; CPT1; CPTASE; IIAE4
External IDs OMIM600650 MGI109176 HomoloGene77 ChEMBL: 3238 GeneCards: CPT2 Gene
EC number 2.3.1.21
RNA expression pattern
PBB GE CPT2 204264 at tn.png
PBB GE CPT2 204263 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1376 12896
Ensembl ENSG00000157184 ENSMUSG00000028607
UniProt P23786 P52825
RefSeq (mRNA) NM_000098 NM_009949
RefSeq (protein) NP_000089 NP_034079
Location (UCSC) Chr 1:
53.66 – 53.68 Mb
Chr 4:
107.9 – 107.92 Mb
PubMed search [1] [2]

Carnitine O-palmitoyltransferase 2, mitochondrial is an enzyme that in humans is encoded by the CPT2 gene.[1][2]

Carnitine palmitoyltransferase II precursor (CPT2) is a nuclear protein which is transported to the mitochondrial inner membrane. CPT2 together with carnitine palmitoyltransferase I oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders and carnitine palmitoyltransferase II deficiency.[2]

Acyl-CoA from cytosol to the mitochondrial matrix


See also[edit]

References[edit]

  1. ^ Minoletti F, Colombo I, Martin AL, Di Donato S, Taroni F, Finocchiaro G, Pandolfo M (Sep 1992). "Localization of the human gene for carnitine palmitoyltransferase to 1p13-p11 by nonradioactive in situ hybridization". Genomics 13 (4): 1372–1374. doi:10.1016/0888-7543(92)90076-5. PMID 1339389.  (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
  2. ^ a b "Entrez Gene: CPT2 carnitine palmitoyltransferase II". 

Further reading[edit]