Carol Lynn George

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Dr. Carol Lynn George
Utah State Science Advisor, Carl Lynn George.JPG
Governor Gary R. Herbert and Carol Lynn George, Ph.D. Utah State Science Advisor
Native name Carol Lynn Curchoe
Born 1979 (age 34–35)
Manchester, Connecticut
Fields Stem cell research, cloning, epigenetics
Alma mater University of Connecticut, Sanford-Burnham Medical Research Institute
Thesis Epigenetic reprogramming in cloned livestock (2006)
Known for Being the Utah State Science Advisor
Spouse Thomas George

Carol Lynn George (née Curchoe, born in 1979 in Manchester, Connecticut) is an American reproductive biologist specializing in molecular and cellular biology and biotechnology. Her key contributions to those fields include advances in stem cell culture, epigenetics and reprogramming. She is currently the Utah State Science Advisor, President and CEO of 32ATPs, an adjunct biology faculty at Utah Valley University, and an author of personal essay and fiction.

Career[edit]

Dr. Carol Lynn George is currently the Utah State Science Advisor to Governor Gary R. Herbert. She is responsible for a number of statewide scientific initiatives including; the Utah State STEM Action Center, Governor's Medals for Science and Technology, Work Ready Utah powered by ACT, and other workforce and advanced manufacturing initiatives.

As an undergraduate researcher Dr. George was part of a team that characterized the meat and milk composition of bovine clones[1] that informed the Food and Drug Administration’s (FDA) decision about these products for general consumption.[2] Her dissertation research, performed at the University of Connecticut in the Physiology of Reproduction, and completed in just three years, was one of the fastest graduate degrees ever earned at Uconn.[3] That work characterized the reprogramming of imprinted genes, such as IGF2,[4] IGF2R,[5] and H19[6] in cloned livestock.[7][8] Her California Institute of Regenerative Medicine postdoctoral work was performed at the Sanford Burnham Medical Research Institute in the field of human embryonic stem cell culture where she developed a protocol for the production of hESC derived neural precursors[9] and peripheral neurons,[10] specifically for therapeutic use. Additionally, she developed an in vitro model of early human neurulation events.[11]

After finishing her academic research she entered the business development community and as an associate at Burnham she was part of a team that strengthened translational research by establishing clinical research partnerships with Pfizer, Takeda, and Johnson & Johnson. In 2010 she helped to launch the Office of Collaborative Science at the NYU Langone School of Medicine, which unified 17 disparate fee for service labs. Best practice models for tracking core-contributed publications[12] resulted. Subsequently, she founded 32ATPs, an international scientific business and management consulting firm in 2011. As a Utah Valley University adjunct faculty she teaches mammalian cloning and biotechnology using project based learning, inverted classrooms, and community building through social media. She has authored one book, The Tip Jar, a compilation of short stories featuring the Wastach Iron Pen award winning short "In Bloom".

Dr. George is known to actively mentor women researchers, staff members and students who are just getting interested in a career in science. She credits the mentorship she received working in the laboratory of Dr. X. Cindy Tian for being able to earn a graduate degree after dropping out of high school. Since relocating to Utah she has been involved with community initiatives such as Latinos in Action, Expanding Your Horizons, Salt Lake Valley Science and Engineering Fair, FIRST and many others.

Personal life[edit]

George was born in Connecticut, of French Canadian descent (Fournier family lineage), the second child of Cora Hall and Richard Curchoe. She has four siblings; sisters, Kelly and Denise and brothers, Jason and Christopher, a sister-in law Ingrid, and numerous nieces and nephews. George earned an Associate of Science degree at Manchester Community College, a bachelor’s degree, master’s degree, and Ph.D. at the University of Connecticut, and performed her postdoctoral research at Sanford-Burnham Institute for Medical Research as a California Institute for Regenerative Medicine funded postdoctoral scholar. She is married to Thomas George, Theatrical Scenic Designer and University of Utah faculty in the Department of Fine Arts.

Honors and awards[edit]

  • Utah Business Magazine's 40 Under 40 Award, 2014
  • Appointed to the Office of the State Science Advisor by Governor Gary R. Herbert, 2013 
  • Wasatch Iron Pen, 2013 
  • First Runner Up Fishman Award, 2009 
  • Presidents Doctoral Dissertation Award, 2006 
  • Environmental Leadership Award Finalist, 2005 
  • Second Runner Up, Poster, Second Annual Asian Reproductive Biology Conference, 2005 
  • Student Life Award Finalist, 2005 
  • Fisher Scientific Trainee Award, 2003 

References[edit]

  1. ^ Tian, X. C.; Kubota, C.; Sakashita, K.; Izaike, Y.; Okano, R.; Tabara, N.; Curchoe, C.; Jacob, L.; Zhang, Y.; Smith, S.; Bormann, C.; Xu, J.; Sato, M.; Andrew, S.; Yang, X. (2005). "Meat and milk compositions of bovine clones". Proceedings of the National Academy of Sciences 102 (18): 6261–6. doi:10.1073/pnas.0500140102. PMC 1088367. PMID 15829585. 
  2. ^ <http://www.fda.gov/downloads/AnimalVeterinary/SafetyHealth/AnimalCloning/UCM124756.pdf}
  3. ^ http://homerweb.lib.uconn.edu/cgi-bin/Pwebrecon.cgi?DB=local&BOOL1=all+of+these&FLD1=Keyword+Anywhere+(GKEY)&CNT=25+records+per+page&SAB1=74494433
  4. ^ Curchoe, C.; Zhang, S; Bin, Y; Zhang, X; Yang, L; Feng, D; O'Neill, M; Tian, XC (2005). "Promoter-Specific Expression of the Imprinted IGF2 Gene in Cattle (Bos taurus)". Biology of Reproduction 73 (6): 1275–81. doi:10.1095/biolreprod.105.044727. PMID 16120826. 
  5. ^ Suteevun-Phermthai, T.; Curchoe, C.L.; Evans, A.C.; Boland, E.; Rizos, D.; Fair, T.; Duffy, P.; Sung, L.Y.; Du, F.; Chaubal, S.; Xu, J.; Wechayant, T.; Yang, X.; Lonergan, P.; Parnpai, R.; Tian, X.C. (2009). "Allelic switching of the imprinted IGF2R gene in cloned bovine fetuses and calves". Animal Reproduction Science 116 (1–2): 19–27. doi:10.1016/j.anireprosci.2009.01.003. PMID 19217227. 
  6. ^ Curchoe, Carol Lynn; Zhang, Shouquan; Yang, Lan; Page, Raymond; Tian, X. Cindy (2009). "Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle". Animal Reproduction Science 116 (3–4): 213–25. doi:10.1016/j.anireprosci.2009.02.008. PMID 19282114. 
  7. ^ Li*, Chao; Bin, Yanfang; Curchoe, Carol; Yang, Lan; Feng, Dingyuan; Jiang, Qingyan; O'Neill, Michael; Tian, X. Cindy et al. (2008). "Genetic Imprinting ofH19andIGF2in Domestic Pigs (Sus scrofa)". Animal Biotechnology 19 (1): 22–7. doi:10.1080/10495390701758563. PMID 18228173. 
  8. ^ Tian, XC; Smith, SL; Zhang, SQ; Kubota, C; Curchoe, C; Xue, F; Yang, L; Du, F; Sung, LY; Yang, X (2007). "Nuclear reprogramming by somatic cell nuclear transfer--the cattle story". Society of Reproduction and Fertility supplement 64: 327–39. PMID 17491157. 
  9. ^ Cimadamore, Flavio; Curchoe, Carol Lynn; Alderson, Nazilla; Scott, Fiona; Salvesen, Guy; Terskikh, Alexey V. (2009). "Nicotinamide Rescues Human Embryonic Stem Cell-Derived Neuroectoderm from Parthanatic Cell Death". Stem Cells 27 (8): 1772–81. doi:10.1002/stem.107. PMID 19544437. 
  10. ^ Curchoe, Carol Lynn; Maurer, Jochen; McKeown, Sonja J.; Cattarossi, Giulio; Cimadamore, Flavio; Nilbratt, Mats; Snyder, Evan Y.; Bronner-Fraser, Marianne et al. (2010). "Early Acquisition of Neural Crest Competence During hESCs Neuralization". In Najbauer, Joseph. PLoS ONE 5 (11): e13890. doi:10.1371/journal.pone.0013890. PMC 2976694. PMID 21085480. 
  11. ^ Curchoe, Carol Lynn; Russo, Joseph; Terskikh, Alexey V. (2012). "HESC derived neuro-epithelial rosettes recapitulate early mammalian neurulation events; an in vitro model". Stem Cell Research 8 (2): 239–46. doi:10.1016/j.scr.2011.11.003. PMID 22265743. 
  12. ^ http://www.ncbi.nlm.nih.gov/pubmed/23204927

External links[edit]