Carolyn R. Bertozzi

Carolyn R. Bertozzi
Born	May 19, 1966(1966-05-19) Boston, Massachusetts
Fields	chemistry
Institutions	University of California, Berkeley Lawrence Berkeley National Laboratory University of California, San Francisco
Alma mater	Harvard University University of California, Berkeley University of California, San Francisco
Known for	bioorthogonal chemistry
Notable awards	MacArthur Foundation Fellowship (1999) Lemelson-MIT Prize (2010)

Carolyn Ruth Bertozzi (* 19 May 1966) is an American chemist. She is the T.Z. and Irmgard Chu Distinguished Professor of Chemistry and Professor of Molecular and Cell Biology at the University of California, Berkeley; Professor of Molecular and Cellular Pharmacology at the University of California, San Francisco; is an Investigator of the Howard Hughes Medical Institute; and is the former Director of the Molecular Foundry, a nanoscience research center at Lawrence Berkeley National Laboratory. She received a MacArthur "genius" award at age 33, making her one of the youngest scientists to receive this award^{[citation needed]}. In 2010 she was the first woman to receive the prestigious Lemelson-MIT Prize faculty award. She is a member of the National Academy of Sciences and the Institute of Medicine.

Biography

Born in Boston, Massachusetts, Bertozzi received her Bachelor's Degree summa cum laude in chemistry from Harvard University, where she worked with Professor Joe Grabowski on the design and construction of a photoacoustic calorimeter. While an undergraduate, she played in a rock band with future Rage Against the Machine guitarist Tom Morello. After graduating she worked briefly at Bell Labs with Chris Chidsey and at Massachusetts General Hospital.

Bertozzi completed her Ph.D. at UC Berkeley in 1993 with Professor Mark Bednarski, working on the chemical synthesis of oligosaccharide analogs. She then was a postdoctoral fellow at UCSF with Professor Steven Rosen, where she studied the activity of endothelial oligosaccharides in promoting cell adhesion at inflammation sites. Bertozzi joined the UC Berkeley faculty in 1996.

Bertozzi studies the glycobiology underlying diseases such as cancer, inflammatory disorders such as arthritis, and infectious diseases such as tuberculosis. In particular, Bertozzi has advanced understanding of cell surface oligosaccharides involved in cell recognition and inter-cellular communication.^{[citation needed]} Bertozzi is credited for developing the field of bioorthogonal chemistry which employs a bioorthogonal chemical reporters, such as the azide to label biomolecules within living systems. Her lab has also developed tools for research, including chemical tools for studying glycans in living systems and more recently nanotechnologies for probing biological systems.^{[citation needed]}

In addition to her academic work, several of the technologies developed in her lab have been adapted for commercial use in biotechnology start-ups.

Significant papers and publications

• Mahal, Lara K.; Yarema, Kevin J.; Bertozzi, Carolyn R. (1997). "Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis". Science 276 (5315): 1125–8. doi:10.1126/science.276.5315.1125. PMID 9173543. 
• Bertozzi, Carolyn R.; Kiessling, Laura L. (2001). "Chemical Glycobiology". Science 291 (5512): 2357–64. doi:10.1126/science.1059820. PMID 11269316. 
• Saxon, Eliana; Bertozzi, Carolyn R. (2000). "Cell Surface Engineering by a Modified Staudinger Reaction". Science 287 (5460): 2007–10. doi:10.1126/science.287.5460.2007. PMID 10720325. 
• Prescher, Jennifer A.; Bertozzi, Carolyn R. (2005). "Chemistry in living systems". Nature Chemical Biology 1 (1): 13–21. doi:10.1038/nchembio0605-13. PMID 16407987. 
• Wang, Peng George; Bertozzi, Carolyn R., eds. (2001). Glycochemistry: Principles, Synthesis, and Applications. New York: Marcel Dekker. ISBN 978-0-8247-0538-1. 

Awards and honors

Carolyn Bertozzi, receiving the Emanuel Merck Lectureship in 2011

• Phi Beta Kappa (1987)
• Arthur C. Cope Scholar Award of the American Chemical Society (1999)
• MacArthur Fellowship (1999)
• Berkeley's Distinguished Teaching Award (2001)
• Donald Sterling Noyce Prize for Excellence in Undergraduate Teaching (2001)
• Fellow of the American Association for the Advancement of Science (2002)
• Irving Sigal Young Investigator Award of the Protein Society (2002)
• Fellow of the American Academy of Arts and Sciences (2003)
• Agnes Fay Morgan Research Award of Iota Sigma Pi (2004)
• Havinga Medal, Univ. Leiden (2005)
• Member of the National Academy of Sciences (2005)
• Ernst Schering Prize (2007)
• Willard Gibbs Award (2008)
• Lemelson-MIT Prize (2010)
• ACS Award in Pure Chemistry
• Merck Academic Development Program Award
• Glaxo Wellcome Scholars' Award
• Presidential Early Career Award in Science and Engineering
• Camille Dreyfus Teacher-Scholar Award
• Hoarce S. Isbell Award in Carbohydrate Chemistry
• Alfred P. Sloan Research Fellowship
• Emanuel Merck Lectureship (2011)

External links

• Bertozzi profile at Bertozzi Lab
• Carolyn Bertozzi's iBioSeminar on Chemical Glycobiology
• Mary Beth Gardiner, "The Right Chemistry" (profile of Bertozzi), HHMI Bulletin Winter 2005, available at http://www.hhmi.org/bulletin/pdf/winter2005/Bertozzi.pdf