Caroverine

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Caroverine
Caroverine.png
Systematic (IUPAC) name
1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one
Clinical data
Legal status Prescription only
Routes Oral
Identifiers
CAS number 23465-76-1
ATC code A03AX11
PubChem CID 65709
ChemSpider 59135 YesY
UNII XJ73B0K6KB YesY
ChEMBL CHEMBL1729803
Chemical data
Formula C22H27N3O2 
Mol. mass 365.47 g/mol
 YesY (what is this?)  (verify)

Caroverine (Spasmium, Spadon) is a drug used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.[1] It also has potent antioxidant effects.[1][2]

References[edit]

  1. ^ a b c Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H (2003). "The Antioxidant Activity of Caroverine". Biochemical Pharmacology 65 (1): 59–65. doi:10.1016/S0006-2952(02)01452-1. PMID 12473379. 
  2. ^ Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV (2003). "Caroverine, a Multifunctional Drug with Antioxidant Functions". BioFactors 19 (1–2): 79–85. doi:10.1002/biof.5520190110. PMID 14757980.