Casomorphin

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Bovine β-casomorphin 7, a casomorphin, has seven amino acids in its peptide sequence.

Casomorphins are peptides, i.e., protein fragments, derived from the digestion of milk protein casein.[1]

Health[edit]

Digestive enzymes can break casein down into peptides that have some biological activity in cells and in laboratory animals though conclusive causal effects on humans have not been established.[1] They have also not been proven to be formed in the human digestive system.[2]

Although research has shown high rates of use of complementary and alternative therapies for children with autism, including gluten and/or casein exclusion diets, as of 2008 there was a lack of evidence that these diets had any effect.[3]

Some known casomorphins[edit]

β-Casomorphin 1-3[edit]

  • Structure: H-Tyr-Pro-Phe-OH
  • Chemical formula: C23H27N3O5
  • Molecular weight: 425.48 g/mol

Bovine β-casomorphin 1-4[edit]

  • Structure: H-Tyr-Pro-Phe-Pro-OH
  • Chemical formula: C28H35N4O6
  • Molecular weight: 522.61 g/mol

Bovine β-casomorphin 1-4, amide[edit]

  • Structure: H-Tyr-Pro-Phe-Pro-NH2
  • Chemical formula: C28H35N5O5
  • Molecular weight: 521.6 g/mol

Also known as morphiceptin

Bovine β-casomorphin 5[edit]

  • Structure: H-Tyr-Pro-Phe-Pro-Gly-OH
  • Chemical formula: C30H37N5O7
  • Molecular weight: 594.66 g/mol

Bovine β-casomorphin 7[edit]

  • Structure: H-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-OH
  • Chemical formula: C41H55N7O9
  • Molecular weight: 789.9 g/mol

Bovine β-casomorphin 8[edit]

  • Structure: H-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-Pro-OH
  • Chemical formula: C46H62N8O10
  • Molecular weight: 887.00 g/mol

(Note: There is also a form of bovine β-Casomorphin 8 that has histidine instead of proline in position 8, depending on whether it is derived from A1 or A2 beta-casein.)

References[edit]

  1. ^ a b European Food Safety Authority. 1 February 2009 Review of the potential health impact of β-casomorphins and related peptides
  2. ^ Clemens, RA (2011). "Milk A1 and A2 peptides and diabetes" (PDF). Nestle Nutr Workshop Ser Pediatr Program 67: 187–95. doi:10.1159/000325584. PMID 21335999. 
  3. ^ Millward, C; Ferriter, M; Calver, S; Connell-Jones, G (2008). "Gluten- and casein-free diets for autistic spectrum disorder". Cochrane Database of Systematic Reviews: CD003498. doi:10.1002/14651858.CD003498.pub3.