Caspase 13 is an enzyme known as a cysteine protease that was identified in cattle that is also called "Evolutionarily Related Interleukin-1β Converting Enzyme" (ERICE). It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. Although this enzyme was originally reported as a human caspase that could be activated by caspase 8, later studies confirmed the gene identified for caspase 13 came from bovine origin, and is the likely orthologue of human caspase 4.
- ^ Humke EW, Ni J, Dixit VM (1998). "ERICE, a novel FLICE-activatable caspase". J. Biol. Chem. 273 (25): 15702–7. doi:10.1074/jbc.273.25.15702. PMID 9624166.
- ^ Koenig U, Eckhart L, Tschachler E (2001). "Evidence that caspase-13 is not a human but a bovine gene". Biochem. Biophys. Res. Commun. 285 (5): 1150–4. doi:10.1006/bbrc.2001.5315. PMID 11478774.
- ^ NCBI Sequence Viewer v2.0
- The MEROPS online database for peptidases and their inhibitors: C14.017