Caspase 6

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Caspase 6, apoptosis-related cysteine peptidase
Protein CASP6 PDB 1MI9.png
Rendering based on PDB 1MI9.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CASP6 ; MCH2
External IDs OMIM601532 MGI1312921 HomoloGene37455 ChEMBL: 3308 GeneCards: CASP6 Gene
EC number 3.4.22.59
RNA expression pattern
PBB GE CASP6 209790 s at tn.png
PBB GE CASP6 211464 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 839 12368
Ensembl ENSG00000138794 ENSMUSG00000027997
UniProt P55212 O08738
RefSeq (mRNA) NM_001226 NM_009811
RefSeq (protein) NP_001217 NP_033941
Location (UCSC) Chr 4:
110.61 – 110.62 Mb
Chr 3:
129.9 – 129.91 Mb
PubMed search [1] [2]

Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene.[1][2] CASP6 orthologs [3] have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Caspase 6 can also undergo self-processing without other members of the caspase family.[4] Alternative splicing of this gene results in two transcript variants that encode different isoforms.[5]

Interactions[edit]

Caspase 6 has been shown to interact with Caspase 8.[6][7][8]

References[edit]

  1. ^ Tiso N, Pallavicini A, Muraro T, Zimbello R, Apolloni E, Valle G, Lanfranchi G, Danieli GA (Oct 1996). "Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis". Biochem Biophys Res Commun 225 (3): 983–9. doi:10.1006/bbrc.1996.1282. PMID 8780721. 
  2. ^ Fernandes-Alnemri T, Litwack G, Alnemri ES (Aug 1995). "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family". Cancer Res 55 (13): 2737–42. PMID 7796396. 
  3. ^ "OrthoMaM phylogenetic marker: CASP6 coding sequence". 
  4. ^ Wang XJ, Cao Q, Liu X, Wang KT, Mi W, Zhang Y, Li LF, LeBlanc AC, Su XD (Nov 2010). "Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation". EMBO Rep 11 (11): 841–7. doi:10.1038/embor.2010.141. PMC 2966951. PMID 20890311. 
  5. ^ "Entrez Gene: CASP6 caspase 6, apoptosis-related cysteine peptidase". 
  6. ^ Cowling, V; Downward J (Oct 2002). "Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain". Cell Death Differ. (England) 9 (10): 1046–56. doi:10.1038/sj.cdd.4401065. ISSN 1350-9047. PMID 12232792. 
  7. ^ Guo, Yin; Srinivasula Srinivasa M, Druilhe Anne, Fernandes-Alnemri Teresa, Alnemri Emad S (Apr 2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem. (United States) 277 (16): 13430–7. doi:10.1074/jbc.M108029200. ISSN 0021-9258. PMID 11832478. 
  8. ^ Srinivasula, S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S (Dec 1996). "Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (25): 14486–91. doi:10.1073/pnas.93.25.14486. ISSN 0027-8424. PMC 26159. PMID 8962078. 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C14.005

See also[edit]

Further reading[edit]