Castanospermine

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Castanospermine[1][2]
Castanospermine.png
Identifiers
CAS number 79831-76-8 YesY
PubChem 54445
ChemSpider 49177 N
ChEBI CHEBI:27860 N
ChEMBL CHEMBL311226 N
Jmol-3D images Image 1
Properties
Molecular formula C8H15NO4
Molar mass 189.209 g/mol
Appearance White to off-white solid
Melting point 212-215 °C
Solubility in water Soluble
Hazards
R-phrases R20/21/22
S-phrases S26 S36
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Castanospermine is an indolizine alkaloid first isolated from the seeds of Castanospermum australe.[3] It is a potent inhibitor of some glucosidase enzymes[4] and has antiviral activity.[5]

See also[edit]

References[edit]

  1. ^ Merck Index, 11th Edition, 1902.
  2. ^ Castanospermine at Fermentek
  3. ^ Hohenschutz, Liza D.; Bell, E. Arthur; Jewess, Phillip J.; Leworthy, David P.; Pryce, Robert J.; Arnold, Edward; Clardy, Jon (1981). "Castanospermine, a 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe". Phytochemistry 20 (4): 811–14. doi:10.1016/0031-9422(81)85181-3. 
  4. ^ R Saul, J J Ghidoni, R J Molyneux, and A D Elbein (1985). "Castanospermine inhibits alpha-glucosidase activities and alters glycogen distribution in animals". PNAS 82 (1): 93–97. doi:10.1073/pnas.82.1.93. PMC 396977. PMID 3881759. 
  5. ^ Whitby K, Pierson TC, Geiss B, Lane K, Engle M, Zhou Y, Doms RW, Diamond MS (2005). "Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo". J Virol 79 (14): 8698–706. doi:10.1128/JVI.79.14.8698-8706.2005. PMC 1168722. PMID 15994763.