It is particularly remembered for a Piedmontese victory over a pontifical army composed of foreign volunteers defending the Papal States, on September 18, 1860. The town's Museum of the Risorgimento, in the palazzo Mordini, commemorates the battle and places it in the wider context of the Risorgimento as a whole. It houses artefacts and documents of the period, including around 130 loans from private collections or other museums.
Castelfidardo is also known as the international capital of accordion builders. A variety of other musical instruments besides the accordion have been produced in the town since the 19th century, such as the armonica.