CatSper2

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cation channel, sperm associated 2
Identifiers
Symbol CATSPER2
External IDs OMIM607249 MGI2387404 HomoloGene77423 IUPHAR: CatSper2 GeneCards: CATSPER2 Gene
Orthologs
Species Human Mouse
Entrez 117155 212670
Ensembl ENSG00000166762 ENSMUSG00000033486
UniProt Q96P56 Q3UQJ3
RefSeq (mRNA) NM_172095 NM_153075
RefSeq (protein) NM_054020 NP_694715
Location (UCSC) Chr 15:
41.71 – 41.75 Mb
Chr 2:
121.22 – 121.24 Mb
PubMed search [1] [2]

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.[1][2] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[3]

Function[edit]

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.[4]

References[edit]

  1. ^ Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491. 
  2. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 
  3. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  4. ^ "Entrez Gene: CatSper2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.